The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …

Interferon (IFN)-I and IFN-II both induce IFN-stimulated gene (ISG) expression through Janus
kinase (JAK)-dependent phosphorylation of signal transducer and activator of transcription …

Interferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen
infections by controlling inflammation and immune response by directly inducing anti …

Abstract Interferon-γ (IFN-γ) coordinates a diverse array of cellular programs through
transcriptional regulation of immunologically relevant genes. This article reviews the current …

The vertebrate transcription factor NF-κB is induced by over 150 different stimuli. Active NF-
κB, in turn, participates in the control of transcription of over 150 target genes. Because a …

▪ Abstract The phytohemagglutinin-induced virus-inhibitor may, however, be produced in
white cells in response to a stimulation of cellular RNA synthesis and may be a feedback …

Interferon regulatory factors (IRFs) constitute a family of transcription factors that commonly
possess a novel helix-turn-helix DNA-binding motif. Following the initial identification of two …

Accurate reconstruction of the regulatory networks that control gene expression is one of the
key current challenges in molecular biology. Although gene expression and chromatin state …

Interferon-stimulated genes (ISGs) are a group of gene products that coordinately combat
pathogen invasions, in particular viral infections. Transcription of ISGs occurs rapidly upon …

Macrophage produced inducible nitric oxide synthase (iNOS) is known to play a critical role
in the proinflammatory response against intracellular pathogens by promoting the …