Benzimidazole is a heterocyclic ring system that has been widely studied in the
pharmaceutical field. For the past decade, numerous benzimidazole derivatives have been …

Out of several heterocyclic templates, the use of a Benzimidazole (BZ) scaffold is immensely
observed. This fused heterocycle comprises two ring nitrogen atoms placed at 1st and 3rd …

The development of next-generation antimalarials that are efficacious against the human
liver and asexual blood stages is recognized as one of the world's most pressing public …

Toxoplasmosis is caused by Toxoplasma gondii and in immunocompromised patients it may
lead to seizures, encephalitis or death. The conserved enzyme prolyl-tRNA synthetase …

Cancer is the second leading cause of death globally, with 9.6 million deaths yearly. As a life‐
threatening disease, it necessitates the emergence of new therapies. Resistance to current …

Aminoacyl-tRNA synthetases (ARSs) catalyze the ligation of amino acids to their cognate
transfer RNAs and are indispensable enzymes for protein biosynthesis in all the cells …

In this study, we evaluate the association between vaginal and cervical human
papillomavirus infections high-risk types (HPV+ H), negative controls (HPV−), the bacterial …

Prolyl-tRNA synthetase (PRS) is a clinically validated antimalarial target. Screening of a set
of PRS ATP-site binders, initially designed for human indications, led to identification of 1 …

Prolyl-tRNA synthetase (PRS) is a member of the aminoacyl-tRNA synthetase family of
enzymes and catalyzes the synthesis of prolyl-tRNA Pro using ATP, l-proline, and tRNA Pro …

Scleroderma has clinical characteristics including skin and other tissue fibrosis, but there is
an unmet need for anti-fibrotic therapy. Halofuginone (HF) is a well-known anti-fibrosis agent …