Tetraspanins: structure, dynamics, and principles of partner-protein recognition

KJ Susa, AC Kruse, SC Blacklow - Trends in cell biology, 2024 - cell.com
Tetraspanins are a large, highly conserved family of four-pass transmembrane (TM) proteins
that play critical roles in a variety of essential cellular functions, including cell migration …

Migrasomes, a new mode of intercellular communication

Y Jiang, X Liu, J Ye, Y Ma, J Mao, D Feng… - Cell Communication and …, 2023 - Springer
Migrasomes are newly discovered extracellular vesicles (EVs) that are formed in migrating
cells and mediate intercellular communication. However, their size, biological generation …

Tetraspanin 4 stabilizes membrane swellings and facilitates their maturation into migrasomes

R Dharan, Y Huang, SK Cheppali, S Goren… - Nature …, 2023 - nature.com
Migrasomes are newly discovered cell organelles forming by local swelling of retraction
fibers. The migrasome formation critically depends on tetraspanin proteins present in the …

The versatile roles of testrapanins in cancer from intracellular signaling to cell–cell communication: cell membrane proteins without ligands

Z Zhou, Z Yang, L Zhou, M Yang, S He - Cell & Bioscience, 2023 - Springer
The tetraspanins (TSPANs) are a family of four-transmembrane proteins with 33 members in
mammals. They are variably expressed on the cell surface, various intracellular organelles …

CD44 promotes angiogenesis in myocardial infarction through regulating plasma exosome uptake and further enhancing FGFR2 signaling transduction

Q Zhang, L Chen, L Huang, H Cheng, L Wang, L Xu… - Molecular …, 2022 - Springer
Background Since angiogenesis occurs as the pathological process following myocardial
infarction to alleviate ischemia, therapeutic angiogenesis has been proposed to be a …

Membrane organization by tetraspanins and galectins shapes lymphocyte function

L Querol Cano, VME Dunlock… - Nature Reviews …, 2024 - nature.com
Immune receptors are not randomly distributed at the plasma membrane of lymphocytes but
are segregated into specialized domains that function as platforms to initiate signalling, as …

Prognostic value and multifaceted roles of tetraspanin CD9 in cancer

R Ondruššek, B Kvokačková, K Kryštofová… - Frontiers in …, 2023 - frontiersin.org
CD9 is a crucial regulator of cell adhesion in the immune system and plays important
physiological roles in hematopoiesis, blood coagulation or viral and bacterial infections. It is …

Migrasome biogenesis: When biochemistry meets biophysics on membranes

D Wang, L Yu - Trends in Biochemical Sciences, 2024 - cell.com
Migrasomes, newly identified organelles, play crucial roles in intercellular communication,
contributing to organ development and angiogenesis. These vesicles, forming on retraction …

Supported natural membranes on microspheres for protein–protein interaction studies

SK Cheppali, R Dharan, R Katzenelson… - ACS Applied Materials …, 2022 - ACS Publications
Multiple biological and pathological processes, such as signaling, cell–cell communication,
and infection by various viruses, occur at the plasma membrane. The eukaryotic plasma …

Migrasomes trigger innate immune activation and mediate transmission of senescence signals across human cells

X Liu, H Jiao, B Zhang, S Zhang, K Yan, J Qu… - Life …, 2023 - academic.oup.com
Aging is a complex and heterogeneous process, raising important questions about how
aging is differently impacted by underlying genetics and external factors. Recently …