As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth
cells, neutrophils, and epithelial cells, contributing to host defense. Their biological functions …

Background: Periodontitis is an immune-inflammatory disease that leads to the progressive
destruction of bone and connective tissue in the periodontal area. The cytokine network …

Brucella is a typical facultative intracellular bacterium that can cause zoonotic infections. For
Brucella, it is difficult to eliminate with current medical treatment. Therefore, a multi-epitope …

There is a growing interest in the complex role of host defense peptides (HDPs) in the
pathophysiology of several immune-mediated inflammatory diseases. The physicochemical …

Tet-eleven translocation 1 (TET1) is a dioxygenase that plays an important role in
decreasing the abundance of DNA methylation and changing the expression levels of …

Periodontitis is recognized as the major cause of tooth loss in adults, posing an adverse
impact on systemic health. In periodontitis, excessive production of reactive oxygen species …

Diabetic wound (DW) is the most devastating complication resulting in significant mortality
and morbidity in diabetic patients. The standard treatment of DW care fails to address the …

The recent epidemic caused by aerosolized SARS-CoV-2 virus illustrates the importance
and vulnerability of the mucosal epithelial barrier against infection. Antimicrobial proteins …

Objective: To investigate the involvement of IL-6/STAT3 signaling pathway activation in
macrophage polarization and bone destruction related to apical periodontitis (AP) stimulated …

Orthodontic force-induced osteogenic differentiation and bone formation at tension side play
a pivotal role in orthodontic tooth movement (OTM). Platelet-derived growth factor-BB (PDGF …