[HTML][HTML] Mechanisms and regulation of defensins in host defense
As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth
cells, neutrophils, and epithelial cells, contributing to host defense. Their biological functions …
cells, neutrophils, and epithelial cells, contributing to host defense. Their biological functions …
Central regulatory role of cytokines in periodontitis and targeting options
G Plemmenos, E Evangeliou… - Current medicinal …, 2021 - ingentaconnect.com
Background: Periodontitis is an immune-inflammatory disease that leads to the progressive
destruction of bone and connective tissue in the periodontal area. The cytokine network …
destruction of bone and connective tissue in the periodontal area. The cytokine network …
[HTML][HTML] Design of a multi-epitope vaccine candidate against Brucella melitensis
M Li, Y Zhu, C Niu, X Xie, G Haimiti, W Guo, M Yu… - Scientific Reports, 2022 - nature.com
Brucella is a typical facultative intracellular bacterium that can cause zoonotic infections. For
Brucella, it is difficult to eliminate with current medical treatment. Therefore, a multi-epitope …
Brucella, it is difficult to eliminate with current medical treatment. Therefore, a multi-epitope …
[HTML][HTML] Expression and function of host defense peptides at inflammation sites
SV Prasad, K Fiedoruk, T Daniluk, E Piktel… - International journal of …, 2019 - mdpi.com
There is a growing interest in the complex role of host defense peptides (HDPs) in the
pathophysiology of several immune-mediated inflammatory diseases. The physicochemical …
pathophysiology of several immune-mediated inflammatory diseases. The physicochemical …
[HTML][HTML] TET1 Knockdown Inhibits Porphyromonas gingivalis LPS/IFN-γ-Induced M1 Macrophage Polarization through the NF-κB Pathway in THP-1 Cells
Y Huang, C Tian, Q Li, Q Xu - International Journal of Molecular Sciences, 2019 - mdpi.com
Tet-eleven translocation 1 (TET1) is a dioxygenase that plays an important role in
decreasing the abundance of DNA methylation and changing the expression levels of …
decreasing the abundance of DNA methylation and changing the expression levels of …
Polydopamine functionalized mesoporous silica as ROS-sensitive drug delivery vehicles for periodontitis treatment by modulating macrophage polarization
B Bai, C Gu, X Lu, X Ge, J Yang, C Wang, Y Gu… - Nano Research, 2021 - Springer
Periodontitis is recognized as the major cause of tooth loss in adults, posing an adverse
impact on systemic health. In periodontitis, excessive production of reactive oxygen species …
impact on systemic health. In periodontitis, excessive production of reactive oxygen species …
[HTML][HTML] Human beta defensin-2 loaded PLGA nanoparticles impregnated in collagen-chitosan composite scaffold for the management of diabetic wounds
Diabetic wound (DW) is the most devastating complication resulting in significant mortality
and morbidity in diabetic patients. The standard treatment of DW care fails to address the …
and morbidity in diabetic patients. The standard treatment of DW care fails to address the …
[HTML][HTML] Antimicrobial peptides: Defending the mucosal epithelial barrier
KF Johnstone, MC Herzberg - Frontiers in Oral Health, 2022 - frontiersin.org
The recent epidemic caused by aerosolized SARS-CoV-2 virus illustrates the importance
and vulnerability of the mucosal epithelial barrier against infection. Antimicrobial proteins …
and vulnerability of the mucosal epithelial barrier against infection. Antimicrobial proteins …
[HTML][HTML] Macrophage M1 polarization mediated via the IL-6/STAT3 pathway contributes to apical periodontitis induced by Porphyromonas gingivalis
X Chen, J Dou, Z Fu, Y Qiu, L Zou, D Huang… - Journal of Applied Oral …, 2022 - SciELO Brasil
Objective: To investigate the involvement of IL-6/STAT3 signaling pathway activation in
macrophage polarization and bone destruction related to apical periodontitis (AP) stimulated …
macrophage polarization and bone destruction related to apical periodontitis (AP) stimulated …
[HTML][HTML] Tensile force-induced PDGF-BB/PDGFRβ signals in periodontal ligament fibroblasts activate JAK2/STAT3 for orthodontic tooth movement
Y Jin, L Ding, Z Ding, Y Fu, Y Song, Y Jing, Q Li… - Scientific Reports, 2020 - nature.com
Orthodontic force-induced osteogenic differentiation and bone formation at tension side play
a pivotal role in orthodontic tooth movement (OTM). Platelet-derived growth factor-BB (PDGF …
a pivotal role in orthodontic tooth movement (OTM). Platelet-derived growth factor-BB (PDGF …