Although multiple pancreatic islet single-cell RNA-sequencing (scRNA-seq) datasets have
been generated, a consensus on pancreatic cell states in development, homeostasis and …

The importance of sexual dimorphism has been highlighted in recent years since the
National Institutes of Health's mandate on considering sex as a biological variable. Although …

The pancreatic islet is the functional and structural unit of the pancreatic endocrine portion.
Islet remodeling occurs in both normal development and pathogenesis of type 1 (T1D) and …

Abstract Development of the human pancreas requires the precise temporal control of gene
expression via epigenetic mechanisms and the binding of key transcription factors. We …

This review thoroughly explores the multifaceted roles of sexual hormones, emphasizing
their impact beyond reproductive functions and underscoring their significant influence on …

Background Current approaches to profile the single-cell transcriptomics of human
pancreatic endocrine cells almost exclusively rely on freshly isolated islets. However, human …

Dopamine (DA) D2-like receptors in both the central nervous system (CNS) and the
periphery are key modulators of metabolism. Moreover, disruption of D2-like receptor …

Abstract Aims Hypertension (HTN) and Type 2 Diabetes (T2D) often coexist, therefore
understanding the relationship between both diseases is imperative to guide targeted …

The existence of functionally diverse and plastic β cells in islets of Langerhans has been
reported since the 1980s. Recently, high-resolution technologies have advanced our …

The role of endogenous Cellular Communication Network factor 5 (CCN5) expression on
normal β-cells growth and insulin resistance caused by diet-induced obesity. Metabolic …