Stem cells have self-renewal capacities and the ability to give rise to differentiated cells
thereby sustaining tissues during homeostasis and injury. This structural hierarchy extends …

Attention has long focused on the actin cytoskeleton as a unit capable of organizing into
ensembles that control cell shape, polarity, migration and the establishment of intercellular …

The airway epithelium serves as the interface between the host and external environment. In
many chronic lung diseases, the airway is the site of substantial remodeling after injury …

The last decade has seen a surge of evidence supporting the existence of the transition of
the multicellular tissue from a collective material phase that is regarded as being jammed to …

Cancer cells are mechanically sensitive to physical properties of the microenvironment,
which can affect downstream signaling to promote malignancy, in part through the …

Mechanical cues in the tumor microenvironment interplay with internal cellular processes to
control cancer cell migration. Microscale pores present in tumor tissue confer varying …

The study of metabolism is undergoing a renaissance. Since the year 2002, over 50
genetically-encoded fluorescent indicators (GEFIs) have been introduced, capable of …

Intracellular and environmental cues result in heterogeneous cancer cell populations with
different metabolic and migratory behaviors. Although glucose metabolism and epithelial-to …

The response of cells to forces is critical for their function and occurs via rearrangement of
the actin cytoskeleton. Cytoskeletal remodelling is energetically costly,, yet how cells signal …

Cancer metastasis is the leading cause of cancer-related mortality and the process of the
epithelial-to-mesenchymal transition (EMT) is crucial for cancer metastasis. Both partial and …