Adults with Down syndrome develop the neuropathological hallmarks of Alzheimer's
disease and are at very high risk of developing early-onset dementia, which is now the …

Autosomal dominant Alzheimer's disease (ADAD) and Down syndrome (DS) constitute
genetic forms of Alzheimer's disease (AD). The study of these forms has been crucial in …

Microglia are critical in brain development and Alzheimer's disease (AD) etiology. Down
syndrome (DS) is the most common genetic developmental disorder and risk factor for AD …

Oxidative stress is a key contributor to AD pathology. However, the earliest role of pre-
plaque neuronal oxidative stress, remains elusive. Using laser microdissected hippocampal …

Abstract Introduction People with Down syndrome (DS) are predisposed to Alzheimer's
disease (AD). The amyloid hypothesis informs studies of AD. In AD‐DS, but not sporadic AD …

CDKL5 deficiency disorder (CDD), a rare and severe neurodevelopmental disease caused
by mutations in the X-linked CDKL 5 gene, is characterized by early-onset epilepsy …

In tauopathies such as Alzheimer's disease (AD) and frontotemporal dementia (FTD), the
microtubule associated protein tau undergoes conformational and posttranslational …

The appearance of cognitive deficits and altered brain morphology in newborns with Down
syndrome (DS) suggests that these features are driven by disruptions at the earliest stages …

Epidemiological evidence suggests that by the age of 40 years, all individuals with Down
syndrome (DS) have Alzheimer's disease (AD) neuropathology. Clinical diagnosis of …

Innate immune system activation and inflammation are associated with and may contribute
to clinical outcomes in people with Down syndrome (DS), neurodegenerative diseases such …