Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …

Objective To compare the risk for all cause and overdose mortality in people with opioid
dependence during and after substitution treatment with methadone or buprenorphine and …

Background Retention in opioid substitution (OST) treatment is associated with substantial
reductions in all cause and overdose mortality. This systematic review aims to identify both …

Objectives. We examined the association between the expansion of methadone and
buprenorphine treatment and the prevalence of heroin overdose deaths in Baltimore …

AIM: To summarize the major findings of the five Cochrane reviews on substitution
maintenance treatments for opioid dependence. METHODS: We conducted a narrative and …

Background Research on clinical application of oral naltrexone agrees on several things.
From a pharmacological perspective, naltrexone works. From an applied perspective, the …

Aims To review evidence on the effectiveness of opioid maintenance treatment (OMT) in
prison and post‐release. Methods Systematic review of experimental and observational …

Opioid dependence is a problem of national concern, especially with dramatically increased
rates of abuse and dependence of prescription opioids. The current article provides an up-to …

Objective To investigate the effect of opiate substitution treatment at the beginning and end
of treatment and according to duration of treatment. Design Prospective cohort study. Setting …

The British Association for Psychopharmacology guidelines for the treatment of substance
abuse, harmful use, addiction and comorbidity with psychiatric disorders primarily focus on …