Vaccines and monoclonal antibody treatments to prevent severe coronavirus disease 2019
(COVID-19) illness were available within a year of the pandemic being declared but there …

Studies have shown that SARS-CoV-2 has the ability to activate and mature proinflammatory
cytokines in the body. Cytokine markers are a group of polypeptide signalling molecules that …

Alopecia areata (AA) is a relapsing, chronic, immune-mediated disease characterized by
nonscarring, inflammatory hair loss that can affect any hair-bearing site. AA clinical …

The altered activation or overexpression of protein kinases (PKs) is a major subject of
research in oncology and their inhibition using small molecules, protein kinases inhibitors …

The signal transducer and activator of transcription (STAT) is a family of intracellular
cytoplasmic transcription factors involved in many biological functions in mammalian signal …

Abstract Purpose The Coronavirus disease 2019 (COVID-19) pandemic is one of the most
devastating global problems. Regarding the lack of disease-specific treatments, repurposing …

Baricitinib (BTB) is an orally administered Janus kinase inhibitor, therapeutically used for the
treatment of rheumatoid arthritis. Recently it has also been approved for the treatment of …

Spinal cord injury (SCI) is a severe neurological injury caused by traffic accidents, trauma, or
falls, which leads to significant loss of sensory, motor, and autonomous functions and …

Covid-19 variants transmissibility was quantitatively analyzed in silico to understand the
reaction mechanisms and to find the reaction inhibitors. Especially, SARS-CoV-2 omicron …

Over the last 25 years, inhibition of Janus kinases (JAKs) has been pursued as a modality
for treating various immune and inflammatory disorders. While the clinical development of …