The direct lineage reprogramming of one specialized cell type into another using defined
factors has fundamentally re-shaped traditional concepts regarding the epigenetic stability of …

Cellular reprogramming technology has created new opportunities in understanding human
disease, drug discovery, and regenerative medicine. While a combinatorial code was …

Direct lineage conversion offers a new strategy for tissue regeneration and disease
modelling. Despite recent success in directly reprogramming fibroblasts into various cell …

Cardiac regeneration is a rapidly evolving and controversial field of research. The
identification some 12 years ago of progenitor cells that reside within the heart spurred …

Direct reprogramming of fibroblasts into cardiomyocytes by forced expression of
cardiomyogenic factors, GMT (GATA4, Mef2C, Tbx5) or GHMT (GATA4, Hand2, Mef2C …

Rationale: Generation of induced cardiac myocytes (iCMs) directly from fibroblasts offers
great opportunities for cardiac disease modeling and cardiac regeneration. A major …

Recent studies have been successful at utilizing ectopic expression of transcription factors to
generate induced cardiomyocytes (iCMs) from fibroblasts, albeit at a low frequency in vitro …

Fibroblasts can be directly reprogrammed into cardiomyocyte-like cells (iCMs) by
overexpression of cardiac transcription factors, including Gata4, Mef2c, and Tbx5; however …

Various combinations of cardiogenic transcription factors, including Gata4 (G), Hand2 (H),
Mef2c (M) and Tbx5 (T), can reprogram fibroblasts into induced cardiac-like myocytes …

The discovery of induced pluripotent stem cells changed the field of regenerative medicine
and inspired the technological development of direct reprogramming or the process by …