Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

Microtubule-targeting agents (MTAs) such as paclitaxel and the vinca alkaloids are among
the most important medical weapons available to combat cancer. MTAs interfere with …

DNA materials have emerged as potential nanocarriers for targeted cancer therapy to
precisely deliver cargos with specific purposes. The short half‐life and low bioavailability of …

Novel indazole and benzimidazole analogues were designed and synthesized as tubulin
inhibitors with potent antiproliferative activities. Among them, compound 12b exhibited the …

Abstract Background Small interfering RNA (siRNA) is utilized as a potent agent for cancer
therapy through regulating the expression of genes associated with tumors. While the widely …

We previously reported a potent tubulin inhibitor CH-2-77. In this study, we optimized the
structure of CH-2-77 by blocking metabolically labile sites and synthesized a series of CH-2 …

Class III β-tubulin (βIII-tubulin) is frequently overexpressed in human tumors and is
associated with resistance to microtubule-targeting agents, tumor aggressiveness, and poor …

Microtubules (MTs), highly dynamic structures composed of α-and β-tubulin heterodimers,
are involved in cell movement and intracellular traffic and are essential for cell division …

Plants are an important source of chemically diverse natural products that target
microtubules, one of the most successful targets in cancer therapy. Colchicine, paclitaxel …

Herein, a series of quinazoline and heterocyclic fused pyrimidine analogues were designed
and synthesized based on the X-ray co-crystal structure of lead compound 3a, showing …