Although cardiac abnormalities have been observed in a growing class of human disorders
caused by defective primary cilia, the function of cilia in the heart remains an underexplored …

Cells need to sense their mechanical environment during the growth of developing tissues
and maintenance of adult tissues. The concept of force-sensing mechanisms that act …

The breaking of bilateral symmetry in most vertebrates is critically dependent upon the
motile cilia of the embryonic left-right organizer (LRO), which generate a directional fluid …

Motile cilia are miniature, propeller-like extensions, emanating from many cell types across
the body. Their coordinated beating generates a directional fluid flow, which is essential for …

One of the vital functions of naturally occurring cilia is fluid transport. Biological cilia use
spatially asymmetric strokes to generate a net fluid flow that can be utilized for feeding …

Understanding how left–right (LR) asymmetry is generated in vertebrate embryos is an
important problem in developmental biology. In humans, a failure to align the left and right …

The initial breaking of left-right (L–R) symmetry in the embryo is controlled by a motile-cilia-
driven leftward fluid flow in the left-right organiser (LRO), resulting in L–R asymmetric gene …

Cilia are hair‐like structures that project from the surface of cells. In vertebrates, most cells
have an immotile primary cilium that mediates cell signaling, and some specialized cells …

Vital internal organs display a left-right (LR) asymmetric arrangement that is established
during embryonic development. Disruption of this LR asymmetry—or laterality—can result in …

The establishment of left–right (LR) asymmetry is fundamental to animal development, but
the identification of a unifying mechanism establishing laterality across different phyla has …