Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders

MS Uddin, A Al Mamun, M Jakaria… - Science of the Total …, 2020 - Elsevier
Neurological disorders represent a great challenge and are the leading cause of death and
disability globally. Although numerous complicated mechanisms are involved in the …

Sulforaphane: A review of its therapeutic potentials, advances in its nanodelivery, recent patents, and clinical trials

B Mangla, S Javed, MH Sultan, P Kumar… - Phytotherapy …, 2021 - Wiley Online Library
Traditionally, herbal supplements have shown an exceptional potential of desirability for the
prevention of diseases and their treatment. Sulforaphane (SFN), an organosulfur compound …

Sulforaphane as a potential protective phytochemical against neurodegenerative diseases

A Tarozzi, C Angeloni, M Malaguti… - Oxidative medicine …, 2013 - Wiley Online Library
A wide variety of acute and chronic neurodegenerative diseases, including
ischemic/traumatic brain injury, Alzheimer's disease, and Parkinson′ s disease, share …

[HTML][HTML] Crucial facts about health benefits of popular cruciferous vegetables

S Manchali, KNC Murthy, BS Patil - Journal of functional foods, 2012 - Elsevier
The lower incidences of many chronic diseases such as cancer and cardiovascular related
ailments are associated with consumption of vegetables rich dietary regimes and this has …

Protective effect of sulforaphane against oxidative stress: recent advances

CE Guerrero-Beltrán, M Calderón-Oliver… - Experimental and …, 2012 - Elsevier
Sulforaphane [1-isothiocyanate-(4R)-(methylsulfinyl) butane] is a natural dietary
isothiocyanate produced by the enzymatic action of the myrosinase on glucopharanin, a 4 …

Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation

Y Bai, W Cui, Y Xin, X Miao, MT Barati, C Zhang… - Journal of molecular and …, 2013 - Elsevier
This study was to investigate whether sulforaphane (SFN) can prevent diabetic
cardiomyopathy. Type 1 diabetes was induced in FVB mice by multiple intraperitoneal …

Sulforaphane protects against cardiovascular disease via Nrf2 activation

Y Bai, X Wang, S Zhao, C Ma, J Cui… - Oxidative medicine and …, 2015 - Wiley Online Library
Cardiovascular disease (CVD) causes an unparalleled proportion of the global burden of
disease and will remain the main cause of mortality for the near future. Oxidative stress plays …

[HTML][HTML] Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ß/Fyn pathway

Y Xin, Y Bai, X Jiang, S Zhou, Y Wang, KA Wintergerst… - Redox Biology, 2018 - Elsevier
Aims Activation of nuclear factor erythroid 2-related factor 2 (Nrf2) by sulforaphane (SFN)
protects from, and deletion of the Nrf2 gene exaggerates, diabetic cardiomyopathy …

Concentrations of thiocyanate and goitrin in human plasma, their precursor concentrations in brassica vegetables, and associated potential risk for hypothyroidism

P Felker, R Bunch, AM Leung - Nutrition Reviews, 2016 - academic.oup.com
Brassica vegetables are common components of the diet and have beneficial as well as
potentially adverse health effects. Following enzymatic breakdown, some glucosinolates in …

Phytochemicals from plants to combat cardiovascular disease

HR Vasanthi, N ShriShriMal… - Current medicinal …, 2012 - ingentaconnect.com
For many decades, the use of synthetic chemicals as drugs has been effective in the
treatment of most diseases. Moreover, from ancient to modern history, many traditional plant …