Critically ill patients are at high risk for development of life-threatening infection leading to
sepsis and multiple organ failure. Adequate antimicrobial therapy is pivotal for optimizing the …

Successful antibiotic therapy in the critically ill requires sufficient drug concentrations at the
site of infection that kill or suppress bacterial growth. The relationship between antibiotic …

Methods These are the consensus statements and guideline of ASHP, IDSA, the Pediatric
Infectious Diseases Society (PIDS), and SIDP. Guideline panel composition consisted of …

High mortality and morbidity rates associated with severe infections in the critically ill
continue to be a significant issue for the healthcare system. In view of the diverse and …

Optimization of antimicrobial dosing in accordance with pharmacokinetics/
pharmacodynamics targets can improve survival and clinical cure. Dosing regimens for …

Introduction The objective of this study was to describe the pharmacokinetics of vancomycin
in ICU patients and to examine whether contemporary antibiotic dosing results in …

Background. Augmented renal clearance (ARC) or renal hyperfiltration is increasingly
reported in intensive care unit (ICU) patients. The goal of this analysis was to study the …

Despite the development of new agents with activity against Gram-positive bacteria,
vancomycin remains one of the primary antibiotics for critically ill septic patients. Because …

Introduction Achievement of optimal vancomycin exposure is crucial to improve the
management of patients with life-threatening infections caused by susceptible Gram-positive …

Optimal dosing of antimicrobial therapy is pivotal to increase the likelihood of survival in
critically ill patients with sepsis. Drug exposure that maximizes bacterial killing, minimizes …