Thalidomide has a dark history as a teratogen, but in recent years, its derivates have been
shown to function as potent chemotherapeutic agents. These drugs bind cereblon (CRBN) …

Myoblast fusion is crucial for the formation, growth, maintenance and regeneration of healthy
skeletal muscle. Unfortunately, the molecular machinery, cell behaviors, and membrane and …

Our understanding of vertebrate origins and the backbone of human history evolves with
each new fossil find and DNA map. Many species have now had their genomes sequenced …

Developmental biology relies heavily on microscopy to image the finely controlled cell
behaviors that drive embryonic development. Most embryos are large enough that a field of …

A fundamental challenge in developmental biology is to understand how forces produced by
individual cells are patterned in space and time and then integrated to produce stereotyped …

Vertebrate embryos exploit the mutual inhibition between the RA and FGF signalling
pathways to coordinate the proliferative elongation of the main body axis with the …

During vertebrate development, the paraxial mesoderm becomes segmented, forming
somites that will give rise to dermis, axial skeleton and skeletal muscles. Although recently …

Cells must make appropriate fate decisions within a complex and dynamic environment. In
vitro studies indicate that the cytoskeleton acts as an integrative platform for this …

During embryogenesis, chordates pass through a tailbud stage in which the larval tail is
formed. Since acquisition of a tadpole-like tail during tailbud stage is one of the key events in …

Fluorescent tagging has become the strategy of choice for examining the subcellular
localisation of proteins. To develop a versatile community resource for this method in …