Abstract Interferon-γ (IFN-γ) coordinates a diverse array of cellular programs through
transcriptional regulation of immunologically relevant genes. This article reviews the current …

Interferon γ (IFNγ) is a pleiotropic protein secreted by immune cells. IFNγ signals through the
IFNγ receptor, a protein complex that mediates downstream signaling events. Studies into …

Epidermal growth factor receptor (EGFR) exists in the nucleus of highly proliferative cells
where it functions as a transcription factor. Although EGFR has transactivational activity, it …

Accurate cellular localization is crucial for the effective function of most signalling molecules
and nuclear translocation is central to the function of transcription factors. The passage of …

Epidermal growth factor receptor (EGFR) has been detected in the nucleus of cancer cells
and primary tumors for decades. While localized in the nucleus, EGFR functions as a …

Many receptor tyrosine kinases (RTKs) can be detected in the cell nucleus, such as EGFR,
HER‐2, HER‐3, HER‐4, and fibroblast growth factor receptor. EGFR, HER‐2 and HER‐4 …

Aberrant epidermal growth factor receptor (EGFR) signaling is a major characteristic of many
human malignancies including breast cancer. Since the discovery of EGF in 1960's and its …

Interferon-gamma (IFN-γ) has been identified as a crucial factor in determining the
responsiveness to immunotherapy. Produced primarily by natural killer (NK) and T cells, IFN …

Abstract Interferon-gamma (IFN-ϒ) is probably one of the most relevant cytokines
orchestrating the immune response in vertebrates. Although the activities mediated by this …

Interaction of ligands such as epidermal growth factor and interferon‐γ with the extracellular
domains of their plasma membrane receptors results in internalization followed by …