Abstract The Na+/I− symporter (NIS) is an integral plasma membrane glycoprotein that
mediates active I− transport into the thyroid follicular cells, the first step in thyroid hormone …

Iodine is an essential element for thyroid hormone synthesis. The thyroid gland has the
capacity and holds the machinery to handle the iodine efficiently when the availability of …

The Na+/I− symporter (NIS) is an intrinsic membrane protein that mediates the active
transport of iodide into the thyroid and other tissues, such as salivary glands, gastric …

Pendred syndrome is an autosomal recessive disorder characterized by congenital
deafness and thyroid goiter. The thyroid disease typically develops around puberty and is …

Thyroid iodide uptake is basic to the clinical applications of radioiodine. Iodide uptake
occurs across the membrane of the thyroid follicular cells through an active transporter …

Extrathyroidal cancers could potentially be targeted with 131I, if the Na+/I− symporter (NIS)
were functional. Using immunohistochemical methods we probed 1278 human samples with …

The expression of 4 thyroid tissue-specific genes [Na+/I− symporter (NIS), thyroid
peroxidase (TPO), thyroglobulin (Tg), TSH receptor (TSH-R)] as well as of the glucose …

Objective Treatment options for patients with radioactive iodine (RaI) refractory metastases
of differentiated thyroid carcinoma (DTC) are limited. We studied the effects of the multitarget …

Hashimoto56 described dense lymphoid infiltration causing goiter and hypothyroidism in
1912; however, it was not until 1956 that autoantibodies, that is, antithyroglobulin antibodies …

Here we report the analysis of the Na+/I− symporter (NIS) protein expression in 57 thyroid
cancer samples by immunohistochemistry with high-affinity anti-NIS Abs. As many as 70% of …