Various binding modes of tunable metal organic frameworks (MOFs) and functional
DNAzymes (Dzs) synergistically catalyze the emergence of abundant functional …

Conspectus Metal ions can be beneficial or toxic depending on their identity, oxidation state,
and concentration. Therefore, the ability to detect and quantify different types of metal ions …

DNAzyme-based sensors remain at the forefront of metal-ion imaging efforts, but most lack
the subcellular precision necessary to their applications in specific organelles. Here, we …

RNA-cleaving DNAzymes hold great promise as gene silencers, and spatiotemporal control
of their activity through site-specific reactions is crucial but challenging for on-demand …

The intelligent nanomachine usually has a control center to carry out self‐regulation.
Unfortunately, most of the nanomaterials for chemodynamic therapy (CDT) do not have such …

There is intense interest in imaging intracellular metal ions because of their vital roles in
many cellular processes. The challenge has been to develop chemical approaches that can …

Since the initial discovery of ribozymes in the early 1980s, catalytic nucleic acids have been
used in different areas. Compared with protein enzymes, catalytic nucleic acids are …

Abstract Proteolysis Targeting Chimeras (PROTACs) represent a promising therapeutic
modality to address undruggable and resistant issues in drug discovery. However, potential …

The precision and therapeutic potential of CRISPR/Cas9 genome editing are greatly
challenged by the less control over Cas9-mediated DNA cleavage. Herein, we introduce a …

Over the last decade, a series of synergistic advances in the synthesis chemistries and
imaging instruments have largely boosted a significant revolution, in which large-scale …