Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The
uptake and metabolism of amino acids are aberrantly upregulated in many cancers that …

Abstract Over 90 years ago, Otto Warburg's seminal discovery of aerobic glycolysis
established metabolic reprogramming as one of the first distinguishing characteristics of …

Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …

Oncogenic signalling and metabolic alterations are interrelated in cancer cells. mTOR,
which is frequently activated in cancer, controls cell growth and metabolism. mTOR …

Cancer cells must rewire cellular metabolism to satisfy the demands of unbridled growth and
proliferation. As such, most human cancers differ from normal counterpart tissues by a …

This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily
of transporter proteins and their roles in human cells. The SLC superfamily currently …

Summary Background National Comprehensive Cancer Network guidelines consider 18 F-
fluciclovine PET-CT for prostate cancer biochemical recurrence localisation after radical …

Although low risk localised prostate cancer has an excellent prognosis owing to effective
treatments, such as surgery, radiation, cryosurgery and hormone therapy, metastatic …

Cancer cells require a massive supply of nutrients, including sugars and amino acids—the
upregulation of transporters for each nutrient contributes to meet the demand. Distinct from …

Ferroptosis is a regulated form of cell death driven by small molecules or conditions that
induce lipid-based reactive oxygen species (ROS) accumulation. This form of iron …