The bone marrow (BM) is the primary site of adult haematopoiesis, where stromal elements
(eg fibroblasts and mesenchymal stem cells [MSCs]) work in concert to support blood cell …

Metabolic rewiring and cellular reprogramming are trademarks of neoplastic initiation and
progression in acute myeloid leukemia (AML). Metabolic alteration in leukemic cells is often …

Acute myeloid leukemia (AML) is an aggressive hematologic neoplasm resulting from the
malignant transformation of myeloid progenitors. Despite intensive chemotherapy leading to …

New treatment options of acute myeloid leukemia (AML) are rapidly emerging. Pre-clinical
models such as ex vivo cultures are extensively used towards the development of novel …

Nucleoside-based drugs, recognized as purine or pyrimidine analogs, have been potent
therapeutic agents since their introduction in 1950, deployed widely in the treatment of …

The importance of mitochondria is not only limited to energy generation but also in several
physical and chemical processes critical for cell survival. Mitochondria play an essential role …

Tumour microenvironments are hallmarked in many cancer types. In haematological
malignancies, bone marrow (BM) mesenchymal stromal cells (MSC) protect malignant cells …

The blood–testis barrier protects developing germ cells by limiting the entry of xenobiotics
into the adluminal compartment. There is strong evidence that the male genital tract can …

MYC is a powerful transcription factor overexpressed in many human cancers including B
cell and prostate cancers. Antibody therapeutics are exciting opportunities to attack cancers …

Cure rates for acute myeloid leukemia (AML) remain suboptimal; thus, new treatment
strategies are needed for this deadly disease. Artemisia campestris leaves hold significant …