Epidemiology, pathophysiology, and treatment of diverticulitis

LL Strate, AM Morris - Gastroenterology, 2019 - Elsevier
Diverticulitis is a prevalent gastrointestinal disorder that is associated with significant
morbidity and health care costs. Approximately 20% of patients with incident diverticulitis …

Colonic diverticular disease

A Tursi, C Scarpignato, LL Strate, A Lanas… - Nature Reviews …, 2020 - nature.com
Diverticula are outpouchings of the intestinal wall and are common anatomical alterations
detected in the human colon. Colonic diverticulosis (the presence of diverticula in the colon; …

European Society of Coloproctology: guidelines for the management of diverticular disease of the colon

JK Schultz, N Azhar, GA Binda, G Barbara… - Colorectal …, 2020 - Wiley Online Library
Aim The goal of this European Society of Coloproctology (ESCP) guideline project is to give
an overview of the existing evidence on the management of diverticular disease, primarily as …

AGA clinical practice update on medical management of colonic diverticulitis: expert review

AF Peery, A Shaukat, LL Strate - Gastroenterology, 2021 - Elsevier
Colonic diverticulitis is a painful gastrointestinal disease that recurs unpredictably and can
lead to chronic gastrointestinal symptoms. Gastroenterologists commonly care for patients …

Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis

U Styrkarsdottir, SH Lund, G Thorleifsson, F Zink… - Nature …, 2018 - nature.com
Osteoarthritis has a highly negative impact on quality of life because of the associated pain
and loss of joint function. Here we describe the largest meta-analysis so far of osteoarthritis …

New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN

A Monteil, NC Guérineau, A Gil-Nagel… - Physiological …, 2024 - journals.physiology.org
Cell excitability and its modulation by hormones and neurotransmitters involve the concerted
action of a large repertoire of membrane proteins, especially ion channels. Unique …

Pathophysiology of diverticular disease: from diverticula formation to symptom generation

MR Barbaro, C Cremon, D Fuschi, G Marasco… - International Journal of …, 2022 - mdpi.com
Diverticular disease is a common clinical problem, particularly in industrialized countries. In
most cases, colonic diverticula remain asymptomatic throughout life and sometimes are …

Genome-wide association analyses identify 39 new susceptibility loci for diverticular disease

LH Maguire, SK Handelman, X Du, Y Chen, TH Pers… - Nature …, 2018 - nature.com
Diverticular disease is common and has a high morbidity. Treatments are limited owing to
the poor understanding of its pathophysiology. Here, to elucidate its etiology, we performed …

Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms

C Schafmayer, JW Harrison, S Buch, C Lange… - Gut, 2019 - gut.bmj.com
Objective Diverticular disease is a common complex disorder characterised by mucosal
outpouchings of the colonic wall that manifests through complications such as diverticulitis …

S3-leitlinie divertikelkrankheit/divertikulitis–gemeinsame leitlinie der deutschen gesellschaft für gastroenterologie, verdauungs-und stoffwechselkrankheiten (DGVS) …

L Leifeld, CT Germer, S Böhm… - Zeitschrift für …, 2022 - thieme-connect.com
1.1. Hintergrund Die Divertikulose und die Divertikelkrankheit gehören zu den häufigsten
gastroenterolgischen Erscheinungen und Krankheitsbildern. Jeder dritte bis zweite …