Alzheimer's disease (AD) is behaviorally identified by progressive memory impairment and
pathologically characterized by the triad of β-amyloid plaques, neurofibrillary tangles, and …

Tauopathies are a broad set of neurodegenerative dementias characterized by aggregation
of the tau protein into filamentous inclusions that can be found in neurons and glial cells …

Alzheimer's disease, the most common age-related neurodegenerative disease, is
characterized by tau aggregation and associated with disrupted circadian rhythms and …

Alzheimer's disease (AD) is an age-associated neurodegenerative disease characterized by
amyloidosis, tauopathy, and activation of microglia, the brain resident innate immune cells …

The tauopathy-like phenotype observed in the rTg4510 mouse line, in which human
tauP301L expression specifically within the forebrain can be temporally controlled, has …

The aggregation of α-synuclein (αSyn) is considered a key pathophysiological feature of
certain neurodegenerative disorders, collectively termed synucleinopathies. Given that a …

It is well-established that inflammation plays an important role in Alzheimer's disease (AD)
and frontotemporal lobar dementia (FTLD). Inflammation and synapse loss occur in disease …

Apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset
Alzheimer's disease mainly by modulating amyloid-β pathology. APOE ε4 is also shown to …

Selective vulnerability of different brain regions is seen in many neurodegenerative
disorders. The hippocampus and cortex are selectively vulnerable in Alzheimer's disease …

Although doxorubicin (Dox) is an effective chemotherapy medication used extensively in the
treatment of breast cancer, it frequently causes debilitating neurological deficits known as …