Over the last several decades, it has become clear that epigenetic abnormalities may be one
of the hallmarks of cancer. Posttranslational modifications of histones, for example, may play …

The concept of macroautophagy was established in 1963, soon after the discovery of
lysosomes in rat liver. Over the 50 years since, studies of liver autophagy have produced …

Abstract p62/Sqstm1 is a multifunctional protein involved in cell survival, growth and death,
that is degraded by autophagy. Amplification of the p62/Sqstm1 gene, and aberrant …

Autophagy is a highly conserved catabolic process seen in eukaryotes and is essentially a
lysosome-dependent protein degradation pathway. The dysregulation of autophagy is often …

Macroautophagy/autophagy is a fundamental cellular degradation mechanism that
maintains cell homeostasis, regulates cell signaling, and promotes cell survival. Its role in …

The long noncoding RNA HOX transcript antisense RNA (HOTAIR) has been reported to be
an oncogene that influences tumor cell development and that correlates with prognosis in …

Colorectal cancer (CRC) remains a leading cause of cancer death in both men and women
worldwide. Among the factors and mechanisms that are involved in the multifactorial etiology …

The high mortality rate of ovarian cancer is connected with the development of acquired
resistance to multiple cancer drugs, especially cisplatin. Activation of cytoprotective …

Autophagy is an evolutionary conserved intracellular mechanism which helps eukaryotic
cells in maintaining their metabolic state to afford high-efficiency energy requirements. In the …

Autophagy modulation is considered to be a promising programmed cell death mechanism
to prevent and cure a great number of disorders and diseases. The crucial step in designing …