Fibrin mechanical properties and their structural origins

RI Litvinov, JW Weisel - Matrix Biology, 2017 - Elsevier
Fibrin is a protein polymer that is essential for hemostasis and thrombosis, wound healing,
and several other biological functions and pathological conditions that involve extracellular …

Fibrin matrices as (injectable) biomaterials: formation, clinical use, and molecular engineering

IV Roberts, D Bukhary… - Macromolecular …, 2020 - Wiley Online Library
This review focuses on fibrin, starting from biological mechanisms (its production from
fibrinogen and its enzymatic degradation), through its use as a medical device and as a …

[HTML][HTML] Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for …

DB Kell, E Pretorius - Progress in biophysics and molecular biology, 2017 - Elsevier
The chief and largely terminal element of normal blood clotting is considered to involve the
polymerisation of the mainly α-helical fibrinogen to fibrin, with a binding mechanism …

[HTML][HTML] Manipulation of cancer cells in a sessile droplet via travelling surface acoustic waves

H Nam, HJ Sung, J Park, JS Jeon - Lab on a Chip, 2022 - pubs.rsc.org
The behaviours of microparticles inside a sessile droplet actuated by surface acoustic waves
(SAWs) were investigated, where the SAWs produced an acoustic streaming flow and …

Does exercise influence the susceptibility to arterial thrombosis? An integrative perspective

LN Olsen, M Fischer, PA Evans, L Gliemann… - Frontiers in …, 2021 - frontiersin.org
Arterial thrombosis is the primary cause of death worldwide, with the most important risk
factors being smoking, unhealthy diet, and physical inactivity. However, although there are …

Automated fiber diameter and porosity measurements of plasma clots in scanning electron microscopy images

A Daraei, M Pieters, SR Baker, Z de Lange-Loots… - Biomolecules, 2021 - mdpi.com
Scanning Electron Microscopy (SEM) is a powerful, high-resolution imaging technique
widely used to analyze the structure of fibrin networks. Currently, structural features, such as …

Gelation under stress: impact of shear flow on the formation and mechanical properties of methylcellulose hydrogels

AZ Nelson, Y Wang, Y Wang, AS Margotta… - Soft Matter, 2022 - pubs.rsc.org
We demonstrate that small unidirectional applied-stresses during temperature-induced
gelation dramatically change the gel temperature and the resulting mechanical properties …

Engineered molecular therapeutics targeting fibrin and the coagulation system: a biophysical perspective

F Risser, I Urosev, J López-Morales, Y Sun… - Biophysical reviews, 2022 - Springer
The coagulation cascade represents a sophisticated and highly choreographed series of
molecular events taking place in the blood with important clinical implications. One key …

The effect of hematocrit, fibrinogen concentration and temperature on the kinetics of clot formation of whole blood

U Windberger, C Dibiasi, EM Lotz… - Clinical …, 2020 - content.iospress.com
BACKGROUND: Dynamic mechanical analysis of blood clots can be used to detect the
coagulability of blood. OBJECTIVE: We investigated the kinetics of clot formation by …

Rheology of fibrous gels under compression

C Sun, PK Purohit - Extreme Mechanics Letters, 2022 - Elsevier
A number of biological tissues and synthetic gels consist of a fibrous network infused with
liquid. There have been a few experimental studies of the rheological properties of such gels …