Fragile X syndrome (FXS) is the leading inherited form of intellectual disability and autism
spectrum disorder, and patients can present with severe behavioural alterations, including …

The mental retardation protein FMRP is involved in the transport of mRNAs and their
translation at synapses. Patients with fragile X syndrome, in whom FMRP is absent or …

Fragile X syndrome (FXS) is a neurodevelopmental disorder characterized by variable
cognitive impairment and behavioral disturbances such as exaggerated fear, anxiety and …

Fragile X syndrome is the most common form of inherited mental retardation. The disorder is
mainly caused by the expansion of the trinucleotide sequence CGG located in the 5′ UTR …

The amygdala, perhaps more than any other brain region, has been implicated in numerous
neuropsychiatric and neurodevelopmental disorders. It is part of a system initially evolved to …

The male bias in the incidence of autism spectrum disorders (ASDs) is one of the most
notable characteristics of this group of neurodevelopmental disorders. The etiology of this …

Recent advances in our understanding of the clinical and molecular features of the fragile-X
mental-retardation 1 gene, FMR1, highlight the importance of single-gene disorders. 15 …

Abstract Background Fragile X syndrome (FXS) is a disorder characterized by a variety of
disabilities, including cognitive deficits, attention-deficit/hyperactivity disorder, autism, and …

Compulsive, self-injurious, and autistic behaviors were examined in 31 boys and 29 girls
with fragile X syndrome aged 5 to 20 years. Self-injurious behavior occured in 58% of boys …

Abstract Changes in the fragile X mental retardation 1 gene (FMR1) have been associated
with specific phenotypes, most specifically those of fragile X syndrome (FXS), fragile X …