T cell antigen receptor recognition of antigen-presenting molecules
The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …
[HTML][HTML] More than one reason to rethink the use of peptides in vaccine design
The use of peptides as therapeutics is experiencing renewed enthusiasm owing to
advances in delivery, stability and design. Moreover, there is a growing emphasis on the use …
advances in delivery, stability and design. Moreover, there is a growing emphasis on the use …
[HTML][HTML] A transformer-based model to predict peptide–HLA class I binding and optimize mutated peptides for vaccine design
Human leukocyte antigen (HLA) can recognize and bind foreign peptides to present them to
specialized immune cells, then initiate an immune response. Computational prediction of the …
specialized immune cells, then initiate an immune response. Computational prediction of the …
A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response
Fine-mapping to plausible causal variation may be more effective in multi-ancestry cohorts,
particularly in the MHC, which has population-specific structure. To enable such studies, we …
particularly in the MHC, which has population-specific structure. To enable such studies, we …
[HTML][HTML] HLA class I supertypes: a revised and updated classification
Background Class I major histocompatibility complex (MHC) molecules bind, and present to
T cells, short peptides derived from intracellular processing of proteins. The peptide …
T cells, short peptides derived from intracellular processing of proteins. The peptide …
HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium
JA Noble, AM Valdes, MD Varney, JA Carlson… - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE We report here genotyping data and type 1 diabetes association analyses for
HLA class I loci (A, B, and C) on 1,753 multiplex pedigrees from the Type 1 Diabetes …
HLA class I loci (A, B, and C) on 1,753 multiplex pedigrees from the Type 1 Diabetes …
[HTML][HTML] Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity
D Chessman, L Kostenko, T Lethborg, AW Purcell… - Immunity, 2008 - cell.com
The basis for strong immunogenetic associations between particular human leukocyte
antigen (HLA) class I allotypes and inflammatory conditions like Behçet's disease (HLA-B51) …
antigen (HLA) class I allotypes and inflammatory conditions like Behçet's disease (HLA-B51) …
Specificity of T-cell alloreactivity
NJ Felix, PM Allen - Nature Reviews Immunology, 2007 - nature.com
T-cell alloreactivity is a well-established phenomenon, but its molecular basis has remained
enigmatic. Although there are differences between T-cell recognition of conventional and …
enigmatic. Although there are differences between T-cell recognition of conventional and …
[HTML][HTML] T cell allorecognition via molecular mimicry
T cells often alloreact with foreign human leukocyte antigens (HLA). Here we showed the
LC13 T cell receptor (TCR), selected for recognition on self-HLA-B∗ 0801 bound to a viral …
LC13 T cell receptor (TCR), selected for recognition on self-HLA-B∗ 0801 bound to a viral …
High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanism
T Kawase, Y Morishima, K Matsuo… - Blood, The Journal …, 2007 - ashpublications.org
In allogenic hematopoietic stem-cell transplantation, an effect of HLA locus mismatch in
allele level on clinical outcome has been clarified. However, the effect of each HLA allele …
allele level on clinical outcome has been clarified. However, the effect of each HLA allele …