ARF GTPases and their GEFs and GAPs: concepts and challenges
E Sztul, PW Chen, JE Casanova… - Molecular biology of …, 2019 - Am Soc Cell Biol
Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are
required to develop models of its actions in cells. Studying a protein family in the aggregate …
required to develop models of its actions in cells. Studying a protein family in the aggregate …
[HTML][HTML] Functional unknomics: Systematic screening of conserved genes of unknown function
JJ Rocha, SA Jayaram, TJ Stevens, N Muschalik… - PLoS …, 2023 - journals.plos.org
The human genome encodes approximately 20,000 proteins, many still uncharacterised. It
has become clear that scientific research tends to focus on well-studied proteins, leading to …
has become clear that scientific research tends to focus on well-studied proteins, leading to …
[HTML][HTML] Control of cell signaling by Arf GTPases and their regulators: Focus on links to cancer and other GTPase families
PW Chen, A Gasilina, MP Yadav… - Biochimica et Biophysica …, 2022 - Elsevier
The ADP-ribosylation factors (Arfs) comprise a family of regulatory GTP binding proteins.
The Arfs regulate membrane trafficking and cytoskeleton remodeling, processes critical for …
The Arfs regulate membrane trafficking and cytoskeleton remodeling, processes critical for …
Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex
Cortical collapse factors affect microtubule (MT) dynamics at the plasma membrane. They
play important roles in neurons, as suggested by inhibition of axon growth and regeneration …
play important roles in neurons, as suggested by inhibition of axon growth and regeneration …
An actomyosin-Arf-GEF negative feedback loop for tissue elongation under stress
In response to a pulling force, a material can elongate, hold fast, or fracture. During animal
development, multi-cellular contraction of one region often stretches neighboring tissue …
development, multi-cellular contraction of one region often stretches neighboring tissue …
ARF1–GTP regulates Asrij to provide endocytic control of Drosophila blood cell homeostasis
Drosophila melanogaster larval hematopoiesis is a well-established model to study
mechanisms that regulate hematopoietic niche maintenance and control of blood cell …
mechanisms that regulate hematopoietic niche maintenance and control of blood cell …
The transcriptional landscape of the giant freshwater prawn: Embryonic development and early sexual differentiation mechanisms
N Grinshpan, FAA Abayed, M Wahl… - Frontiers in …, 2022 - frontiersin.org
The giant freshwater prawn pj Macrobrachium rosenbergii is one of the best studied species
in aquaculture. However, the transcriptional changes associated with embryonic …
in aquaculture. However, the transcriptional changes associated with embryonic …
The interplay of Klotho with signaling pathway and microRNAs in cancers
Klotho (KL) gene has been accepted as an" aging suppressor" gene that encodes a single
transmembrane protein in human known as Klotho which is commonly expressed in renal …
transmembrane protein in human known as Klotho which is commonly expressed in renal …
An Arf-GEF regulates antagonism between endocytosis and the cytoskeleton for Drosophila blastoderm development
DM Lee, TJC Harris - Current Biology, 2013 - cell.com
Background Actin cytoskeletal networks push and pull the plasma membrane (PM) to control
cell structure and behavior. Endocytosis also regulates the PM and can be promoted or …
cell structure and behavior. Endocytosis also regulates the PM and can be promoted or …
Dynamic changes in host–virus interactions associated with colony founding and social environment in fire ant queens (Solenopsis invicta)
F Manfredini, DW Shoemaker… - Ecology and …, 2016 - Wiley Online Library
The dynamics of host–parasite interactions can change dramatically over the course of a
chronic infection as the internal (physiological) and external (environmental) conditions of …
chronic infection as the internal (physiological) and external (environmental) conditions of …