ARF GTPases and their GEFs and GAPs: concepts and challenges

E Sztul, PW Chen, JE Casanova… - Molecular biology of …, 2019 - Am Soc Cell Biol
Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are
required to develop models of its actions in cells. Studying a protein family in the aggregate …

[HTML][HTML] Functional unknomics: Systematic screening of conserved genes of unknown function

JJ Rocha, SA Jayaram, TJ Stevens, N Muschalik… - PLoS …, 2023 - journals.plos.org
The human genome encodes approximately 20,000 proteins, many still uncharacterised. It
has become clear that scientific research tends to focus on well-studied proteins, leading to …

[HTML][HTML] Control of cell signaling by Arf GTPases and their regulators: Focus on links to cancer and other GTPase families

PW Chen, A Gasilina, MP Yadav… - Biochimica et Biophysica …, 2022 - Elsevier
The ADP-ribosylation factors (Arfs) comprise a family of regulatory GTP binding proteins.
The Arfs regulate membrane trafficking and cytoskeleton remodeling, processes critical for …

Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex

Y Qu, I Hahn, M Lees, J Parkin, A Voelzmann, K Dorey… - Elife, 2019 - elifesciences.org
Cortical collapse factors affect microtubule (MT) dynamics at the plasma membrane. They
play important roles in neurons, as suggested by inhibition of axon growth and regeneration …

An actomyosin-Arf-GEF negative feedback loop for tissue elongation under stress

JJ West, T Zulueta-Coarasa, JA Maier, DM Lee… - Current Biology, 2017 - cell.com
In response to a pulling force, a material can elongate, hold fast, or fracture. During animal
development, multi-cellular contraction of one region often stretches neighboring tissue …

ARF1–GTP regulates Asrij to provide endocytic control of Drosophila blood cell homeostasis

RJ Khadilkar, D Rodrigues, RD Mote… - Proceedings of the …, 2014 - National Acad Sciences
Drosophila melanogaster larval hematopoiesis is a well-established model to study
mechanisms that regulate hematopoietic niche maintenance and control of blood cell …

The transcriptional landscape of the giant freshwater prawn: Embryonic development and early sexual differentiation mechanisms

N Grinshpan, FAA Abayed, M Wahl… - Frontiers in …, 2022 - frontiersin.org
The giant freshwater prawn pj Macrobrachium rosenbergii is one of the best studied species
in aquaculture. However, the transcriptional changes associated with embryonic …

The interplay of Klotho with signaling pathway and microRNAs in cancers

M Abolghasemi, T Yousefi, M Maniati… - Journal of Cellular …, 2019 - Wiley Online Library
Klotho (KL) gene has been accepted as an" aging suppressor" gene that encodes a single
transmembrane protein in human known as Klotho which is commonly expressed in renal …

An Arf-GEF regulates antagonism between endocytosis and the cytoskeleton for Drosophila blastoderm development

DM Lee, TJC Harris - Current Biology, 2013 - cell.com
Background Actin cytoskeletal networks push and pull the plasma membrane (PM) to control
cell structure and behavior. Endocytosis also regulates the PM and can be promoted or …

Dynamic changes in host–virus interactions associated with colony founding and social environment in fire ant queens (Solenopsis invicta)

F Manfredini, DW Shoemaker… - Ecology and …, 2016 - Wiley Online Library
The dynamics of host–parasite interactions can change dramatically over the course of a
chronic infection as the internal (physiological) and external (environmental) conditions of …