Genetic mosaicism is the result of the accumulation of somatic mutations in the human
genome starting from the first postzygotic cell generation and continuing throughout the …

Despite enormous efforts employing various approaches, the molecular pathology in the
schizophrenia brain remains elusive. On the other hand, the knowledge of the association …

Bipolar disorder (BD) is a global medical issue, afflicting around 1% of the population with
manic and depressive episodes. Despite various genetic studies, the genetic architecture …

Objective Brain somatic mutations in mTOR pathway genes are a major genetic etiology of
focal cortical dysplasia type II (FCDII). Despite a greater ability to detect low‐level somatic …

This article reviews the current progress in our understanding of the mechanisms by which
growth factors, including brain-derived neurotrophic factor (BDNF) and vascular endothelial …

Research efforts over the past decade have defined the genetic landscape of somatic
variation in the brain. Neurons accumulate somatic mutations from development through …

Accumulation of somatic mutations in human neurons is associated with aging and
neurodegeneration. To shed light on the somatic mutational burden in Alzheimer's disease …

Mutations, the irreversible changes in an organism's DNA sequence, are present in tissues
at a variant allele frequency (VAF) ranging from~ 10-8 per bp for a founder mutation to~ 10-3 …

Low-level somatic mutations in the human brain are implicated in various neurological
disorders. The contribution of low-level brain somatic mutations to autism spectrum disorder …

The long interspersed nuclear elements 1 (LINE-1/L1s) are the only active autonomous
retrotransposons found in humans which can integrate anywhere in the human genome …