The statins have been used for 30 years to prevent coronary artery disease and stroke. Their
primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic …

With cardiovascular disease being the leading cause of morbidity and mortality worldwide,
effective and cost-efficient therapies to reduce cardiovascular risk are highly needed. Lipids …

Statins, among the most commonly prescribed drugs worldwide, are cholesterol-lowering
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently …

▪ Abstract Statins are potent inhibitors of cholesterol biosynthesis. In clinical trials, statins are
beneficial in the primary and secondary prevention of coronary heart disease. However, the …

Figure 2. Regulation of the Rho GTPase cycle. Rho protein cycle between an inactive GDP-
bound and an active GTP-bound state. Inhibition of the mevalonate synthesis by statins …

Nitric oxide (NO) was originally discovered as a vasodilator product of the endothelium. Over
the last 15 years, this vascular mediator has been shown to have important antiplatelet …

Currently, five different statins (simvastatin, pravastatin, lovastatin, fluvastatin, and
atorvastatin) are approved for treatment of hypercholesterolemia in humans and two new …

Nitric oxide (NO) is undoubtedly quite an important intercellular messenger in cerebral and
peripheral hemodynamics. This molecule, formed by constitutive isomers of NO synthase …

Statins represent the cornerstone of pharmacotherapy for the prevention of atherosclerotic
cardiovascular disease. These medications not only reduce low-density lipoprotein …

Background: Atorvastatin is very effective in reducing plasma low-density lipoprotein
cholesterol (LDL-C) levels. However, there is no long-term survival study that evaluated this …