The eradication of malaria will only be possible if effective, well-tolerated medicines kill
hypnozoites in vivax and ovale malaria, and thus prevent relapses in patients. Despite …

The unicellular protozoan parasites of the genus Plasmodium impose on human health
worldwide the enormous burden of malaria. The possibility to genetically modify several …

The development of therapies and vaccines for human hepatropic pathogens requires
robust model systems that enable the study of host-pathogen interactions. However, in vitro …

Highlights•Plasmepsin IX and X are essential for parasite egress and invasion in rodent and
human malaria throughout the Plasmodium life cycle.•Efficient genetic manipulation of …

Malaria parasite infection continues to inflict extensive morbidity and mortality in resource-
poor countries. The insufficiently understood parasite biology, continuously evolving drug …

Malaria is a devastating parasitic disease affecting half of the world's population. The rapid
emergence of resistance against new antimalarial drugs, including artemisinin‐based …

Infection by malaria parasites (Plasmodium spp.) remains one of the leading causes of
morbidity and mortality, especially in tropical regions of the world. Despite the availability of …

Highlights•To achieve malaria elimination novel treatments need to block disease
transmission.•A new generation of antimalarial candidate drugs holds much …

The tumor microenvironment contains unique immune cells, termed myeloid-derived
suppressor cells (MDSCs), and tumor-associated macrophages (TAMs) that suppress host …

Plasmodium vivax is a human malaria parasite responsible for significant morbidity
worldwide and potentially death. This parasite possesses formidable liver-stage biology that …