Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death. Its
mortality has increased in Western populations, with a minority of patients diagnosed at …

Background Controversy exists regarding the optimal negative margin width for ductal
carcinoma in situ (DCIS) treated with breast-conserving surgery and whole-breast irradiation …

Importance Women with ductal carcinoma in situ (DCIS), or stage 0 breast cancer, often
experience a second primary breast cancer (DCIS or invasive), and some ultimately die of …

A vast range of disorders—from indolent to fast-growing lesions—are labelled as cancer.
Therefore, we believe that several changes should be made to the approach to cancer …

Overdiagnosis, and thus overtreatment, are inevitable consequences of most screening
programmes; identification of ways of minimising the impact of overdiagnosis demands new …

Genome sequencing of cancers often reveals mosaics of different subclones present in the
same tumour,–. Although these are believed to arise according to the principles of somatic …

Background Whole breast irradiation (WBI) after conservative surgery for ductal carcinoma
in situ (DCIS) reduces local recurrence. We investigated whether a tumour bed boost after …

An estimated 60,290 new cases of breast carcinoma in situ are expected to be diagnosed in
2015, and approximately 1 in 33 women is likely to receive an in situ breast cancer …

Translating the vast data generated by genomic platforms into accurate predictions of
clinical outcomes is a fundamental challenge in genomic medicine. Many prediction …

Purpose To determine the 12-year risk of developing an ipsilateral breast event (IBE) for
women with ductal carcinoma in situ (DCIS) of the breast treated with surgical excision …