DNA repair deficiency regulates immunity response in cancers: molecular mechanism and approaches for combining immunotherapy
Y Xu, S Nowsheen, M Deng - Cancers, 2023 - mdpi.com
Simple Summary DNA repair pathways play a crucial role in maintaining the stability of a
cell's genetic material. When these pathways are defective, it can lead to genomic instability …
cell's genetic material. When these pathways are defective, it can lead to genomic instability …
New insights into DNA polymerase mechanisms provided by time-lapse crystallography
DNA polymerases play central roles in DNA replication and repair by catalyzing template-
directed nucleotide incorporation. Recently time-lapse X-ray crystallography, which allows …
directed nucleotide incorporation. Recently time-lapse X-ray crystallography, which allows …
[HTML][HTML] Loss-of-function mutation of REV1 (p. R704Q) mediates cetuximab primary resistance by activating autophagy in RAS-wild type metastatic colorectal cancer
N Zhu, Y Ding, M Mi, J Yang, M Yang, D Li, Y Zhang… - Cancer Letters, 2024 - Elsevier
Cetuximab in combination with FOLFIRI/FOLFOX is the standard first-line treatment for
patients with RAS wild-type metastatic colorectal cancer (mCRC). However, some patients …
patients with RAS wild-type metastatic colorectal cancer (mCRC). However, some patients …
Protein assemblies in translesion synthesis
GA Arianna, DM Korzhnev - Genes, 2024 - mdpi.com
Translesion synthesis (TLS) is a mechanism of DNA damage tolerance utilized by eukaryotic
cells to replicate DNA across lesions that impede the high-fidelity replication machinery. In …
cells to replicate DNA across lesions that impede the high-fidelity replication machinery. In …
[HTML][HTML] Mad2B forms a complex with Cdc20, Cdc27, Rev3 and Rev1 in response to cisplatin-induced DNA damage
JH Kim, R Patel - The Korean Journal of Physiology & …, 2023 - synapse.koreamed.org
Mitotic arrest deficient 2 like 2 (Mad2L2, also known as Mad2B), the human homologue of
the yeast Rev7 protein, is a regulatory subunit of DNA polymerase ζ that shares high …
the yeast Rev7 protein, is a regulatory subunit of DNA polymerase ζ that shares high …
Methylation and hydroxymethylation of cytosine alter activity and fidelity of translesion DNA polymerases
ES Shilkin, DV Petrova, AA Novikova, EO Boldinova… - DNA repair, 2024 - Elsevier
Epigenetic cytosine methylation covers most of genomic CpG dinucleotides in human cells.
In addition to common deamination-mediated mutagenesis at CpG sites, an alternative …
In addition to common deamination-mediated mutagenesis at CpG sites, an alternative …
Molecular dependencies and genomic consequences of a global DNA damage tolerance defect
D de Groot, A Spanjaard, R Shah, M Kreft, B Morris… - bioRxiv, 2023 - biorxiv.org
ABSTRACT DNA damage tolerance (DDT) enables replication to continue in the presence
of fork stalling lesions. To determine the molecular and genomic impact of a global DDT …
of fork stalling lesions. To determine the molecular and genomic impact of a global DDT …
Unraveling the Interplay between DNA and Proteins: A Computational Exploration of Sequence and Structure-Specific Recognition Mechanisms
KA Hossain - 2023 - mostwiedzy.pl
My PhD dissertation focused on DNA-protein interactions and the recognition of specific
DNA sequences and structures. I discovered that acidic amino acid residues (Asp/Glu) play …
DNA sequences and structures. I discovered that acidic amino acid residues (Asp/Glu) play …