Somatostatin analogs are an invaluable therapeutic option in the diagnosis and treatment of
somatotropinomas, thyrotropinomas, and functioning and non-functioning …

Pancreatic β-cells are finely tuned to secrete insulin so that plasma glucose levels are
maintained within a narrow physiological range (3.5-5.5 mmol/L). Hyperinsulinaemic …

Background Congenital hyperinsulinism (CHI) is a clinically heterogeneous condition.
Mutations in eight genes (ABCC8, KCNJ11, GLUD1, GCK, HADH, SLC16A1, HNF4A and …

Congenital hyperinsulinism (CHI) is a heterogenous and complex disorder in which the
unregulated insulin secretion from pancreatic beta-cells leads to hyperinsulinaemic …

A female infant of nonconsanguineous Indian parents presented at 4 months with a
hypoglycemic convulsion. Further episodes of hypoketotic hypoglycemia were associated …

Dunne, Mark J., Karen E. Cosgrove, Ruth M. Shepherd, Albert Aynsley-Green, and Keith J.
Lindley. Hyperinsulinism in Infancy: From Basic Science to Clinical Disease. Physiol Rev 84 …

The beta‐cell ATP‐sensitive potassium (KATP) channel is a key component of stimulus‐
secretion coupling in the pancreatic beta‐cell. The channel couples metabolism to …

Congenital hyperinsulinism of infancy (CHI) is characterized by severe hypoglycemia due to
dysregulated insulin secretion, associated with either focal or diffuse pathology of the …

Hyperinsulinemic hypoglycemia (HH) is characterized by unregulated insulin release,
leading to persistently low blood glucose concentrations with lack of alternative fuels, which …

ATP-sensitive potassium channels play a major role in linking metabolic signals to the
exocytosis of insulin in the pancreatic β cell. These channels consist of two types of protein …