Towards organoid culture without Matrigel

MT Kozlowski, CJ Crook, HT Ku - Communications biology, 2021 - nature.com
Organoids—cellular aggregates derived from stem or progenitor cells that recapitulate organ
function in miniature—are of growing interest in developmental biology and medicine …

Bioactive potential of natural biomaterials: Identification, retention and assessment of biological properties

K Joyce, GT Fabra, Y Bozkurt, A Pandit - Signal transduction and …, 2021 - nature.com
Biomaterials have had an increasingly important role in recent decades, in biomedical
device design and the development of tissue engineering solutions for cell delivery, drug …

Decellularization in tissue engineering and regenerative medicine: evaluation, modification, and application methods

A Neishabouri, A Soltani Khaboushan… - … in bioengineering and …, 2022 - frontiersin.org
Reproduction of different tissues using scaffolds and materials is a major element in
regenerative medicine. The regeneration of whole organs with decellularized extracellular …

Tissue-specific decellularization methods: rationale and strategies to achieve regenerative compounds

U Mendibil, R Ruiz-Hernandez… - International journal of …, 2020 - mdpi.com
The extracellular matrix (ECM) is a complex network with multiple functions, including
specific functions during tissue regeneration. Precisely, the properties of the ECM have been …

Decellularization strategies for regenerative medicine: from processing techniques to applications

A Gilpin, Y Yang - BioMed research international, 2017 - Wiley Online Library
As the gap between donors and patients in need of an organ transplant continues to widen,
research in regenerative medicine seeks to provide alternative strategies for treatment. One …

Tissue-engineered grafts from human decellularized extracellular matrices: a systematic review and future perspectives

A Porzionato, E Stocco, S Barbon, F Grandi… - International journal of …, 2018 - mdpi.com
Tissue engineering and regenerative medicine involve many different artificial and biologic
materials, frequently integrated in composite scaffolds, which can be repopulated with …

Methods of tissue decellularization used for preparation of biologic scaffolds and in vivo relevance

TJ Keane, IT Swinehart, SF Badylak - Methods, 2015 - Elsevier
Biologic scaffolds composed of extracellular matrix (ECM) are widely used in both preclinical
animal studies and in many clinical applications to repair and reconstruct tissues. Recently …

Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function

BLM Hogan, CE Barkauskas, HA Chapman, JA Epstein… - Cell stem cell, 2014 - cell.com
Respiratory disease is the third leading cause of death in the industrialized world.
Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of …

Crossing kingdoms: Using decellularized plants as perfusable tissue engineering scaffolds

JR Gershlak, S Hernandez, G Fontana, LR Perreault… - Biomaterials, 2017 - Elsevier
Despite significant advances in the fabrication of bioengineered scaffolds for tissue
engineering, delivery of nutrients in complex engineered human tissues remains a …

Extracellular matrix in lung development, homeostasis and disease

Y Zhou, JC Horowitz, A Naba, N Ambalavanan… - Matrix Biology, 2018 - Elsevier
The lung's unique extracellular matrix (ECM), while providing structural support for cells, is
critical in the regulation of developmental organogenesis, homeostasis and injury-repair …