Gliomas, the most common malignant primary brain tumours, remain universally lethal. Yet,
seminal discoveries in the past 5 years have clarified the anatomy, genetics and function of …

In chronic infections and in cancer, persistent antigen stimulation under suboptimal
conditions can lead to the induction of T-cell exhaustion. Exhausted T cells are …

T cell dysfunction contributes to tumor immune escape in patients with cancer and is
particularly severe amidst glioblastoma (GBM). Among other defects, T cell lymphopenia is …

The brain tumor microenvironment (TME) is emerging as a critical regulator of cancer
progression in primary and metastatic brain malignancies. The unique properties of this …

Glioblastoma is the most common malignant primary brain tumor in adults and is almost
invariably fatal. Despite our growing understanding of the various mechanisms underlying …

Purpose: T-cell dysfunction is a hallmark of glioblastoma (GBM). Although anergy and
tolerance have been well characterized, T-cell exhaustion remains relatively unexplored …

Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma (GBM) trials.
Here, we show that regulatory T (Treg) cells play a key role in GBM resistance to ICBs in …

Glioblastoma is a highly lethal brain cancer with a median survival rate of less than 15
months when treated with the current standard of care, which consists of surgery …

Background Immunotherapies have demonstrated efficacy across a diverse set of tumors
supporting further evaluation in glioblastoma. The objective of this study was to evaluate the …

Glioblastomas (GBMs) are the most common and aggressive primary brain tumors. Due to
their malignant growth and invasion into the brain parenchyma coupled with resistance to …