Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects

M Li, Y Jiang, Q Hou, Y Zhao, L Zhong, X Fu - Stem cell research & …, 2022 - Springer
Mesenchymal stem cell (MSC)-based therapy has been considered as a promising
approach targeting a variety of intractable diseases due to remarkable multiple effect of …

Identifying the therapeutic significance of mesenchymal stem cells

VK Mishra, HH Shih, F Parveen, D Lenzen, E Ito… - Cells, 2020 - mdpi.com
The pleiotropic behavior of mesenchymal stem cells (MSCs) has gained global attention due
to their immense potential for immunosuppression and their therapeutic role in immune …

Functional enhancement strategies for immunomodulation of mesenchymal stem cells and their therapeutic application

BC Lee, KS Kang - Stem cell research & therapy, 2020 - Springer
Mesenchymal stem cells (MSCs) have recently been considered a promising alternative
treatment for diverse immune disorders due to their unique biomedical potentials including …

Intravenous infusion of umbilical cord blood-derived mesenchymal stem cells in rheumatoid arthritis: a phase Ia clinical trial

EH Park, H Lim, S Lee, K Roh, KW Seo… - Stem cells …, 2018 - academic.oup.com
Based on immunomodulatory actions of human umbilical cord blood-derived mesenchymal
stem cells (hUCB-MSCs), in vitro or preclinical studies of hUCB-MSCs have been conducted …

The Use of Human Mesenchymal Stem Cells as Therapeutic Agents for the in vivo Treatment of Immune-Related Diseases: A Systematic Review

A Leyendecker Jr, CCG Pinheiro, MT Amano… - Frontiers in …, 2018 - frontiersin.org
Background: One of the greatest challenges for medicine is to find a safe and effective
treatment for immune-related diseases. However, due to the low efficacy of the treatment …

Lactobacillus fermentum Suo Attenuates HCl/Ethanol Induced Gastric Injury in Mice through Its Antioxidant Effects

H Suo, X Zhao, Y Qian, P Sun, K Zhu, J Li, B Sun - Nutrients, 2016 - mdpi.com
The purpose of the study was to determine the inhibitory effects of Lactobacillus fermentum
Suo (LF-Suo) on HCl/ethanol induced gastric injury in ICR (Institute for Cancer Research) …

Polyphenols targeting MAP kinase signaling pathway in neurological diseases: understanding molecular mechanisms and therapeutic targets

F Islam, S Roy, M Zehravi, S Paul, H Sutradhar… - Molecular …, 2024 - Springer
Polyphenols are a class of secondary metabolic products found in plants that have been
extensively studied for how well they regulate biological processes, such as the proliferation …

FAK-and YAP/TAZ dependent mechanotransduction pathways are required for enhanced immunomodulatory properties of adipose-derived mesenchymal stem cells …

S Wan, X Fu, Y Ji, M Li, X Shi, Y Wang - Biomaterials, 2018 - Elsevier
Adipose-derived mesenchymal stem cells (ASCs) represent an excellent candidate for
tissue engineering due to their multipotency and paracrine functions. Physical cues provided …

DNA damage repair response in mesenchymal stromal cells: From cellular senescence and aging to apoptosis and differentiation ability

H Kahroba, H Sadeghzadeh, DM Wilson III… - Ageing research …, 2020 - Elsevier
Mesenchymal stromal cells (MSCs) are heterogeneous and contain several populations,
including stem cells. MSCs' secretome has the ability to induce proliferation, differentiation …

Cardiac fibrosis in the ageing heart: contributors and mechanisms

L Lu, J Guo, Y Hua, K Huang, R Magaye… - Clinical and …, 2017 - Wiley Online Library
Cardiac fibrosis refers to an excessive deposition of extracellular matrix (ECM) in cardiac
tissue. Fibrotic tissue is stiffer and less compliant, resulting in subsequent cardiac …