Mitochondria are vital organelles with distinct morphological features and functional
properties. The dynamic network of mitochondria undergoes structural and functional …

Neurons have more extended and complex shapes than other cells and consequently face a
greater challenge in distributing and maintaining mitochondria throughout their arbors …

Mitochondria are best known for harboring pathways involved in ATP synthesis through the
tricarboxylic acid cycle and oxidative phosphorylation. Major advances in understanding …

Mitochondria are highly dynamic organelles that constantly migrate, fuse, and divide to
regulate their shape, size, number, and bioenergetic function. Mitofusins (Mfn1/2), optic …

Axonal regeneration in the central nervous system (CNS) is a highly energy-demanding
process. Extrinsic insults and intrinsic restrictions lead to an energy crisis in injured axons …

Changes in neuronal activity create local and transient changes in energy demands at
synapses. Here we discover a metabolic compartment that forms in vivo near synapses to …

Axon regeneration is essential to restore the nervous system after axon injury. However, the
neuronal cell biology that underlies axon regeneration is incompletely understood. Here we …

Many people around the world suffer from some form of paralysis caused by spinal cord
injury (SCI), which has an impact on quality and life expectancy. The spinal cord is part of …

Although neuronal regeneration is a highly energy-demanding process, axonal
mitochondrial transport progressively declines with maturation. Mature neurons typically fail …

Mitochondria are key cellular power plants essential for neuronal growth, survival, function,
and regeneration after injury. Given their unique morphological features, neurons face …