Closed-loop vagus nerve stimulation for the treatment of cardiovascular diseases: state of the art and future directions
The autonomic nervous system exerts a fine beat-to-beat regulation of cardiovascular
functions and is consequently involved in the onset and progression of many cardiovascular …
functions and is consequently involved in the onset and progression of many cardiovascular …
A scoping review of current and emerging techniques for evaluation of peripheral nerve health, degeneration, and regeneration: Part 1, neurophysiology
Peripheral neuroregeneration research and therapeutic options are expanding
exponentially. With this expansion comes an increasing need to reliably evaluate and …
exponentially. With this expansion comes an increasing need to reliably evaluate and …
Organotopic organization of the porcine mid-cervical vagus nerve
Introduction Despite detailed characterization of fascicular organization of somatic nerves,
the functional anatomy of fascicles evident in human and large mammal cervical vagus …
the functional anatomy of fascicles evident in human and large mammal cervical vagus …
Computational modelling of nerve stimulation and recording with peripheral visceral neural interfaces
CD Eiber, SC Payne, NP Biscola… - Journal of neural …, 2021 - iopscience.iop.org
Objective. Neuromodulation of visceral nerves is being intensively studied for treating a wide
range of conditions, but effective translation requires increasing the efficacy and …
range of conditions, but effective translation requires increasing the efficacy and …
Organ-and function-specific anatomical organization and bioelectronic modulation of the vagus nerve
N Jayaprakash, V Toth, W Song, A Vardhan, T Levy… - BioRxiv, 2022 - biorxiv.org
Afferent and efferent fibers in the vagus nerve travel inside fascicles and form branches to
innervate organs and regulate organ functions. The spatial organization of fibers and …
innervate organs and regulate organ functions. The spatial organization of fibers and …
Fibers in smaller fascicles have lower activation thresholds with cuff electrodes due to thinner perineurium and smaller cross-sectional area
CJ Davis, ED Musselman, WM Grill… - Journal of neural …, 2023 - iopscience.iop.org
Objective. In nerve stimulation therapies, fibers in larger fascicles generally have higher
activation thresholds, but the mechanisms are not well understood. We implemented and …
activation thresholds, but the mechanisms are not well understood. We implemented and …
Closed-loop Control of Functional Electrical Stimulation Using a Selectively Recording and Bidirectional Nerve Cuff Interface
YCE Hwang, L Long, J Sales Filho… - … on Neural Systems …, 2024 - ieeexplore.ieee.org
Discriminating recorded afferent neural information can provide sensory feedback for closed-
loop control of functional electrical stimulation, which restores movement to paralyzed limbs …
loop control of functional electrical stimulation, which restores movement to paralyzed limbs …
Organotopic organization of the cervical vagus nerve
Despite detailed characterization of fascicular organization of somatic nerves, the functional
anatomy of fascicles evident in human and large mammal cervical vagus nerve is unknown …
anatomy of fascicles evident in human and large mammal cervical vagus nerve is unknown …
Mapping the functional anatomy and topography of the cardiac autonomic innervation for selective cardiac neuromodulation using MicroCT
Background: Vagus nerve stimulation (VNS) has gained great importance as a promising
therapy for a myriad of diseases. Of particular interest is the therapy of cardiovascular …
therapy for a myriad of diseases. Of particular interest is the therapy of cardiovascular …
Deep-learning segmentation of fascicles from microCT of the human vagus nerve
ON Buyukcelik, M Lapierre-Landry, C Kolluru… - Frontiers in …, 2023 - frontiersin.org
Introduction MicroCT of the three-dimensional fascicular organization of the human vagus
nerve provides essential data to inform basic anatomy as well as the development and …
nerve provides essential data to inform basic anatomy as well as the development and …