Abstract The international American Joint Committee on Cancer/Union for International
Cancer Control (AJCC/UICC) tumour-node-metastasis (TNM) staging system provides the …

Abstract Immune-checkpoint inhibitors (ICBs), in addition to targeting CTLA-4, PD-1, and PD-
L1, novel targeting LAG-3 drugs have also been approved in clinical application. With the …

Chronic inflammation increases the risk of several cancers, including gastric, colon, and
hepatic cancers. Conversely, tumors, similar to tissue injury, trigger an inflammatory …

Brain glioma treatment with checkpoint inhibitor antibodies to cytotoxic T-lymphocyte-
associated antigen 4 (a-CTLA-4) and programmed cell death-1 (a-PD-1) was largely …

Cell-based immunotherapy has become the new-generation cancer medicine, and" off-the-
shelf" cell products that can be manufactured at large scale and distributed readily to treat …

Simple Summary Natural killer T (NKT) cells are a subset of lipid-reactive T cells that
enhance anti-tumor immunity. While preclinical studies have shown NKT cell …

Programmed cell death protein 1 (PD-1), expressed on tumor-infiltrating T cells, is a T cell
exhaustion marker. The mechanisms underlying PD-1 upregulation in CD4 T cells remain …

Cancer immunotherapy has emerged as an effective therapeutic strategy to treat cancer.
Among diverse immune populations, invariant natural killer T (iNKT) cells have shown …

Messenger RNA encoding tumor antigens has the potential to evoke effective antitumor
immunity. This study reports on a nanoparticle platform, named mRNA Galsomes, that …

Immunotherapy that has proven efficacy in several solid cancers plays a partial role in
improving clinical outcomes of advanced gastrointestinal (GI) cancers. There is an unmet …