[HTML][HTML] A critical review of the evidence that metformin is a putative anti-aging drug that enhances healthspan and extends lifespan
I Mohammed, MD Hollenberg, H Ding… - Frontiers in …, 2021 - frontiersin.org
The numerous beneficial health outcomes associated with the use of metformin to treat
patients with type 2 diabetes (T2DM), together with data from pre-clinical studies in animals …
patients with type 2 diabetes (T2DM), together with data from pre-clinical studies in animals …
Basic mechanisms of diabetic heart disease
RH Ritchie, ED Abel - Circulation research, 2020 - Am Heart Assoc
Diabetes mellitus predisposes affected individuals to a significant spectrum of
cardiovascular complications, one of the most debilitating in terms of prognosis is heart …
cardiovascular complications, one of the most debilitating in terms of prognosis is heart …
Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity
G Jia, MA Hill, JR Sowers - Circulation research, 2018 - Am Heart Assoc
Heart failure and related morbidity and mortality are increasing at an alarming rate, in large
part, because of increases in aging, obesity, and diabetes mellitus. The clinical outcomes …
part, because of increases in aging, obesity, and diabetes mellitus. The clinical outcomes …
[HTML][HTML] Molecular machinery and interplay of apoptosis and autophagy in coronary heart disease
Y Dong, H Chen, J Gao, Y Liu, J Li, J Wang - Journal of molecular and …, 2019 - Elsevier
Coronary heart disease (CHD) is a common heart disease and the leading cause of
cardiovascular death. Apoptosis and autophagy are two forms of programmed cell deaths …
cardiovascular death. Apoptosis and autophagy are two forms of programmed cell deaths …
Caloric restriction mimetics against age-associated disease: targets, mechanisms, and therapeutic potential
The increase in life expectancy has boosted the incidence of age-related pathologies
beyond social and economic sustainability. Consequently, there is an urgent need for …
beyond social and economic sustainability. Consequently, there is an urgent need for …
Diabetic cardiomyopathy: a hyperglycaemia-and insulin-resistance-induced heart disease
G Jia, A Whaley-Connell, JR Sowers - Diabetologia, 2018 - Springer
Diabetic cardiomyopathy is characterised in its early stages by diastolic relaxation
abnormalities and later by clinical heart failure in the absence of dyslipidaemia …
abnormalities and later by clinical heart failure in the absence of dyslipidaemia …
Mitophagy is essential for maintaining cardiac function during high fat diet-induced diabetic cardiomyopathy
M Tong, T Saito, P Zhai, S Oka, W Mizushima… - Circulation …, 2019 - Am Heart Assoc
Rationale: Diabetic patients develop cardiomyopathy characterized by hypertrophy, diastolic
dysfunction, and intracellular lipid accumulation, termed lipotoxicity. Diabetic hearts utilize …
dysfunction, and intracellular lipid accumulation, termed lipotoxicity. Diabetic hearts utilize …
[HTML][HTML] Metformin inhibits the NLRP3 inflammasome via AMPK/mTOR-dependent effects in diabetic cardiomyopathy
Metformin is a widely used antidiabetic drug for type 2 diabetes that can play a
cardioprotective role through multiple pathways. It is a recognized agonist of AMP-activated …
cardioprotective role through multiple pathways. It is a recognized agonist of AMP-activated …
[HTML][HTML] Metformin as a tool to target aging
N Barzilai, JP Crandall, SB Kritchevsky, MA Espeland - Cell metabolism, 2016 - cell.com
Aging has been targeted by genetic and dietary manipulation and by drugs in order to
increase lifespan and health span in numerous models. Metformin, which has demonstrated …
increase lifespan and health span in numerous models. Metformin, which has demonstrated …
Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy
G Jia, VG DeMarco, JR Sowers - Nature Reviews Endocrinology, 2016 - nature.com
Insulin resistance, type 2 diabetes mellitus and associated hyperinsulinaemia can promote
the development of a specific form of cardiomyopathy that is independent of coronary artery …
the development of a specific form of cardiomyopathy that is independent of coronary artery …