[HTML][HTML] A critical review of the evidence that metformin is a putative anti-aging drug that enhances healthspan and extends lifespan

I Mohammed, MD Hollenberg, H Ding… - Frontiers in …, 2021 - frontiersin.org
The numerous beneficial health outcomes associated with the use of metformin to treat
patients with type 2 diabetes (T2DM), together with data from pre-clinical studies in animals …

Basic mechanisms of diabetic heart disease

RH Ritchie, ED Abel - Circulation research, 2020 - Am Heart Assoc
Diabetes mellitus predisposes affected individuals to a significant spectrum of
cardiovascular complications, one of the most debilitating in terms of prognosis is heart …

Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity

G Jia, MA Hill, JR Sowers - Circulation research, 2018 - Am Heart Assoc
Heart failure and related morbidity and mortality are increasing at an alarming rate, in large
part, because of increases in aging, obesity, and diabetes mellitus. The clinical outcomes …

[HTML][HTML] Molecular machinery and interplay of apoptosis and autophagy in coronary heart disease

Y Dong, H Chen, J Gao, Y Liu, J Li, J Wang - Journal of molecular and …, 2019 - Elsevier
Coronary heart disease (CHD) is a common heart disease and the leading cause of
cardiovascular death. Apoptosis and autophagy are two forms of programmed cell deaths …

Caloric restriction mimetics against age-associated disease: targets, mechanisms, and therapeutic potential

F Madeo, D Carmona-Gutierrez, SJ Hofer, G Kroemer - Cell metabolism, 2019 - cell.com
The increase in life expectancy has boosted the incidence of age-related pathologies
beyond social and economic sustainability. Consequently, there is an urgent need for …

Diabetic cardiomyopathy: a hyperglycaemia-and insulin-resistance-induced heart disease

G Jia, A Whaley-Connell, JR Sowers - Diabetologia, 2018 - Springer
Diabetic cardiomyopathy is characterised in its early stages by diastolic relaxation
abnormalities and later by clinical heart failure in the absence of dyslipidaemia …

Mitophagy is essential for maintaining cardiac function during high fat diet-induced diabetic cardiomyopathy

M Tong, T Saito, P Zhai, S Oka, W Mizushima… - Circulation …, 2019 - Am Heart Assoc
Rationale: Diabetic patients develop cardiomyopathy characterized by hypertrophy, diastolic
dysfunction, and intracellular lipid accumulation, termed lipotoxicity. Diabetic hearts utilize …

[HTML][HTML] Metformin inhibits the NLRP3 inflammasome via AMPK/mTOR-dependent effects in diabetic cardiomyopathy

F Yang, Y Qin, Y Wang, S Meng, H Xian… - … journal of biological …, 2019 - ncbi.nlm.nih.gov
Metformin is a widely used antidiabetic drug for type 2 diabetes that can play a
cardioprotective role through multiple pathways. It is a recognized agonist of AMP-activated …

[HTML][HTML] Metformin as a tool to target aging

N Barzilai, JP Crandall, SB Kritchevsky, MA Espeland - Cell metabolism, 2016 - cell.com
Aging has been targeted by genetic and dietary manipulation and by drugs in order to
increase lifespan and health span in numerous models. Metformin, which has demonstrated …

Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy

G Jia, VG DeMarco, JR Sowers - Nature Reviews Endocrinology, 2016 - nature.com
Insulin resistance, type 2 diabetes mellitus and associated hyperinsulinaemia can promote
the development of a specific form of cardiomyopathy that is independent of coronary artery …