The nervous system is populated by numerous types of neurons, each bearing a dendritic
arbor with a characteristic morphology. These type-specific features influence many aspects …

As one of the most successful intracellular symbiotic bacteria, Wolbachia can infect many
arthropods and nematodes. Wolbachia infection usually affects the reproduction of their …

The basic mechanisms underlying noxious cold perception are not well understood. We
developed Drosophila assays for noxious cold responses. Larvae respond to near-freezing …

Background Alcohol abuse and alcoholism are significant public health problems, but the
genetic basis for individual variation in alcohol sensitivity remains poorly understood …

Cellular protein homeostasis, or proteostasis, is indispensable to the survival and function of
all cells. Distinct from other cell types, neurons are long-lived, exhibiting architecturally …

Uncovering molecular mechanisms regulating dendritic diversification is essential to
understanding the formation and modulation of functional neural circuitry. Transcription …

Stimulation of cells with epidermal growth factor (EGF) induces internalization and partial
degradation of the EGF receptor (EGFR) by the endo-lysosomal pathway. For continuous …

Dendrite branching is an essential process for building complex nervous systems. It
determines the number, distribution and integration of inputs into a neuron, and is regulated …

Transcription factors (TFs) have emerged as essential cell autonomous mediators of subtype
specific dendritogenesis; however, the downstream effectors of these TFs remain largely …

Dendrites function as the primary sites for synaptic input and integration with impairments in
dendritic arborization being associated with dysfunctional neuronal circuitry. Post-mitotic …