Collagen, the most abundant extracellular matrix protein in animal kingdom belongs to a
family of fibrous proteins, which transfer load in tissues and which provide a highly …

The use of collagen as a biomaterial is currently undergoing a renaissance in the tissue
engineering field. The biotechnological applications focus on the aspects of cellular growth …

Various research groups around the world are actively investigating cardiovascular
prostheses of biological origin. This review article discusses the need for such bioprosthetics …

Calcification plays a major role in the failure of bioprosthetic and other tissue heart valve
substitutes. Tissue valve calcification is initiated primarily within residual cells that have …

The use of glutaraldehyde as a fixative in bioprostheses and drug delivery matrices is
reviewed. The chemistry of glutaraldehyde cross-linking and its effect on the biological …

Collagenous tissue as a biomaterial possesses many favourable characteristics and
advantages over synthetic materials. The resemblance to human tissue suggests that it has …

There is evidence to suggest that the cellular components of homografts and bioprosthetic
xenografts may contribute to calcification or immunogenic reactions. A fourstep detergent …

The physical properties of collagen-based biomaterials are profoundly influenced by the
method and extent of crosslinking. In this study, the influence of various crosslinking …

Substitute heart valves composed of human or animal tissues have been used since the
early 1960s, when aortic valves obtained fresh from human cadavers were transplanted to …

Ectopic calcification is defined as inappropriate biomineralization occurring in soft tissues. 1
Ectopic calcifications are typically composed of calcium phosphate salts, including …