DNA end resection: mechanism and control
P Cejka, LS Symington - Annual review of genetics, 2021 - annualreviews.org
DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genome integrity and
cell viability. Typically, cells repair DSBs by either nonhomologous end joining (NHEJ) or …
cell viability. Typically, cells repair DSBs by either nonhomologous end joining (NHEJ) or …
The plasticity of DNA replication forks in response to clinically relevant genotoxic stress
Complete and accurate DNA replication requires the progression of replication forks through
DNA damage, actively transcribed regions, structured DNA and compact chromatin. Recent …
DNA damage, actively transcribed regions, structured DNA and compact chromatin. Recent …
Mechanisms of vertebrate DNA interstrand cross-link repair
DNA interstrand cross-links (ICLs) covalently connect the two strands of the double helix and
are extremely cytotoxic. Defective ICL repair causes the bone marrow failure and cancer …
are extremely cytotoxic. Defective ICL repair causes the bone marrow failure and cancer …
BRCA2 promotes genomic integrity and therapy resistance primarily through its role in homology-directed repair
Tumor suppressor BRCA2 functions in homology-directed repair (HDR), the protection of
stalled replication forks, and the suppression of replicative gaps, but their relative …
stalled replication forks, and the suppression of replicative gaps, but their relative …
The emerging determinants of replication fork stability
T Thakar, GL Moldovan - Nucleic acids research, 2021 - academic.oup.com
A universal response to replication stress is replication fork reversal, where the nascent
complementary DNA strands are annealed to form a protective four-way junction allowing …
complementary DNA strands are annealed to form a protective four-way junction allowing …
Revisiting the BRCA-pathway through the lens of replication gap suppression:“Gaps determine therapy response in BRCA mutant cancer”
SB Cantor - DNA repair, 2021 - Elsevier
The toxic lesion emanating from chemotherapy that targets the DNA was initially debated,
but eventually the DNA double strand break (DSB) ultimately prevailed. The reasoning was …
but eventually the DNA double strand break (DSB) ultimately prevailed. The reasoning was …
Homology-directed repair protects the replicating genome from metabolic assaults
Homology-directed repair (HDR) safeguards DNA integrity under various forms of stress, but
how HDR protects replicating genomes under extensive metabolic alterations remains …
how HDR protects replicating genomes under extensive metabolic alterations remains …
Targeting replication stress response pathways to enhance genotoxic chemo-and radiotherapy
JA Nickoloff - Molecules, 2022 - mdpi.com
Proliferating cells regularly experience replication stress caused by spontaneous DNA
damage that results from endogenous reactive oxygen species (ROS), DNA sequences that …
damage that results from endogenous reactive oxygen species (ROS), DNA sequences that …
RFWD3 promotes ZRANB3 recruitment to regulate the remodeling of stalled replication forks
CE Moore, SE Yalcindag, H Czeladko… - Journal of Cell …, 2023 - rupress.org
Replication fork reversal is an important mechanism to protect the stability of stalled forks
and thereby preserve genomic integrity. While multiple enzymes have been identified that …
and thereby preserve genomic integrity. While multiple enzymes have been identified that …
The safe path at the fork: ensuring replication-associated DNA double-strand breaks are repaired by homologous recombination
JA Nickoloff, N Sharma, L Taylor, SJ Allen… - Frontiers in …, 2021 - frontiersin.org
Cells must replicate and segregate their DNA to daughter cells accurately to maintain
genome stability and prevent cancer. DNA replication is usually fast and accurate, with …
genome stability and prevent cancer. DNA replication is usually fast and accurate, with …