Deep mutational scanning for therapeutic antibody engineering
The biophysical and functional properties of monoclonal antibody (mAb) drug candidates
are often improved by protein engineering methods to increase the probability of clinical …
are often improved by protein engineering methods to increase the probability of clinical …
Antigenic evolution of human influenza H3N2 neuraminidase is constrained by charge balancing
As one of the main influenza antigens, neuraminidase (NA) in H3N2 virus has evolved
extensively for more than 50 years due to continuous immune pressure. While NA has …
extensively for more than 50 years due to continuous immune pressure. While NA has …
A primer on model-guided exploration of fitness landscapes for biological sequence design
Machine learning methods are increasingly employed to address challenges faced by
biologists. One area that will greatly benefit from this cross-pollination is the problem of …
biologists. One area that will greatly benefit from this cross-pollination is the problem of …
Higher-order epistasis and phenotypic prediction
Contemporary high-throughput mutagenesis experiments are providing an increasingly
detailed view of the complex patterns of genetic interaction that occur between multiple …
detailed view of the complex patterns of genetic interaction that occur between multiple …
Empirical variance component regression for sequence-function relationships
J Zhou, M Wong, WC Chen, A Krainer, J Kinney… - BioRxiv, 2020 - repository.cshl.edu
Contemporary high-throughput mutagenesis experiments are providing an increasingly
detailed view of the complex patterns of genetic interaction that occur between multiple …
detailed view of the complex patterns of genetic interaction that occur between multiple …