Ultrasensitive fluorescent proteins for imaging neuronal activity
Fluorescent calcium sensors are widely used to image neural activity. Using structure-based
mutagenesis and neuron-based screening, we developed a family of ultrasensitive protein …
mutagenesis and neuron-based screening, we developed a family of ultrasensitive protein …
Optimization of a GCaMP calcium indicator for neural activity imaging
Genetically encoded calcium indicators (GECIs) are powerful tools for systems
neuroscience. Recent efforts in protein engineering have significantly increased the …
neuroscience. Recent efforts in protein engineering have significantly increased the …
[HTML][HTML] Recruitment of GABAergic interneurons in the barrel cortex during active tactile behavior
Neural computation involves diverse types of GABAergic inhibitory interneurons that are
integrated with excitatory (E) neurons into precisely structured circuits. To understand how …
integrated with excitatory (E) neurons into precisely structured circuits. To understand how …
Efficient optogenetic silencing of neurotransmitter release with a mosquito rhodopsin
Information is carried between brain regions through neurotransmitter release from axonal
presynaptic terminals. Understanding the functional roles of defined neuronal projection …
presynaptic terminals. Understanding the functional roles of defined neuronal projection …
A disinhibitory microcircuit initiates critical-period plasticity in the visual cortex
Early sensory experience instructs the maturation of neural circuitry in the cortex,. This has
been studied extensively in the primary visual cortex, in which loss of vision to one eye …
been studied extensively in the primary visual cortex, in which loss of vision to one eye …
Rational design of silicon structures for optically controlled multiscale biointerfaces
Silicon-based materials have been widely used in biological applications. However,
remotely controlled and interconnect-free silicon configurations have been rarely explored …
remotely controlled and interconnect-free silicon configurations have been rarely explored …
High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels
Channelrhodopsin-2 (ChR2) has become an indispensable tool in neuroscience, allowing
precise induction of action potentials with short light pulses. A limiting factor for many …
precise induction of action potentials with short light pulses. A limiting factor for many …
Higher-order thalamocortical inputs gate synaptic long-term potentiation via disinhibition
LE Williams, A Holtmaat - Neuron, 2019 - cell.com
Sensory experience and perceptual learning changes receptive field properties of cortical
pyramidal neurons (PNs), largely mediated by synaptic long-term potentiation (LTP). The …
pyramidal neurons (PNs), largely mediated by synaptic long-term potentiation (LTP). The …
NeuroMatic: an integrated open-source software toolkit for acquisition, analysis and simulation of electrophysiological data
JS Rothman, RA Silver - Frontiers in neuroinformatics, 2018 - frontiersin.org
Acquisition, analysis and simulation of electrophysiological properties of the nervous system
require multiple software packages. This makes it difficult to conserve experimental …
require multiple software packages. This makes it difficult to conserve experimental …
Organization of cortical and thalamic input to pyramidal neurons in mouse motor cortex
Determining how long-range synaptic inputs engage pyramidal neurons in primary motor
cortex (M1) is important for understanding circuit mechanisms involved in regulating …
cortex (M1) is important for understanding circuit mechanisms involved in regulating …