Although transplantation procedures have been developed for patients with end-stage
hepatic insufficiency or other diseases, allograft rejection still threatens patient health and …

Glucocorticoids play an important biphasic role in modulating neural plasticity; low doses
enhance neural plasticity and spatial memory behavior, whereas chronic, higher doses …

Understanding individual susceptibility to drug-induced cardiotoxicity is key to improving
patient safety and preventing drug attrition. Human induced pluripotent stem cells (hiPSCs) …

The permeability transition pore (PTP) is a mitochondrial channel whose opening causes
the mitochondrial membrane potential (ΔΨ) collapse that leads to apoptosis. Some …

Accumulating evidence suggests that mitochondrial dysfunction plays a critical role in the
progression of a variety of neurodegenerative and psychiatric disorders. Thus, enhancing …

Background Chronic kidney disease (CKD) is a relatively rare childhood disease that is
associated with a wide array of medical comorbidities. Roughly half of all pediatric patients …

The properties of a proapoptotic 1, 4-benzodiazepine, Bz-423, identified through
combinatorial chemistry and phenotype screening are described. Bz-423 rapidly generated …

Beginning 15 min after induction of intracerebral hemorrhage (ICH) by intrastriatal
administration of collagenase, rats were treated intramuscularly with FK-506 (3 mg/kg) or …

We investigated the effect of two immunosuppressant drugs, FK506 and rapamycin, on
reactive oxygen species (ROS) generation, nitric oxide (NO) production, inducible nitric …

The effects of dehydroepiandrosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S),
α-estradiol and β-estradiol on the main functions of purified rat brain mitochondria were …