Very early-onset lone atrial fibrillation patients have a high prevalence of rare variants in genes previously associated with atrial fibrillation

MS Olesen, L Andreasen, J Jabbari, L Refsgaard… - Heart Rhythm, 2014 - Elsevier
Background Atrial fibrillation (AF) is the most common cardiac arrhythmia. Currently, 14
genes important for ion channel function, intercellular signaling, and homeostatic control …

Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients

CH Lin, CJ Ho, YT Lu, MH Tsai - BMC neurology, 2021 - Springer
Abstract Background Many antiseizure medications (ASMs) control seizures by blocking
voltage-dependent sodium channels. Polymorphisms of sodium channel genes may affect …

Laboratory methods for investigating nuclear and cytoplasmic genomes and transcriptome

XQ Li - Somatic Genome Manipulation: Advances, Methods …, 2015 - Springer
A cell usually has several categories of DNA. For example, the widely used Agrobacterium
tumefaciens system used for plant genetic transformation has a large plasmid called a tumor …

Reduced Penetrance and Variable Expression of Dilated Cardiomyopathy Associated With Biallelic Truncating Variants of NRAP Gene

AM Alqhtani - 2024 - search.proquest.com
Background. Dilated Cardiomyopathy (DCM) is a prevalent form of cardiomyopathy found in
children, characterized by ventricular dilation, systolic dysfunction, and heart failure. Despite …

Integrative analyses identify potential key genes and pathways in Keshan disease using whole-exome sequencing

J Huang, C Zheng, R Luo, M Liu, Q Gu, J Li, X Wu… - medRxiv, 2021 - medrxiv.org
Keshan disease (KD), an endemic heart disease with multifocal necrosis and replacement
fibrosis of the myocardium, is still a nightmare situation for human health. However …

[PDF][PDF] Study to establish genetic association of cardiac conduction defect in Indian patients undergoing pacemaker implantation

S GARDE, P BHATTACHARYYA, M IDRIS… - 2022 - academia.edu
Background: The aim was to study the genetic association of cardiac conduction defects
(CCDs) by evaluating single nucleotide polymorphism (SNP) in genes of SCN1B and …