Recent years have seen considerable progress in simulations of nucleic acids.
Improvements in force fields, simulation techniques and protocols, and increasing computer …

NHP6A is a non-sequence-specific DNA-binding protein from Saccharomyces cerevisiae
which belongs to the HMGB protein family. Previously, we have solved the structure of …

DNA and RNA are known to have different structural properties. In the present study,
molecular dynamics (MD) simulations on a series of RNA and DNA duplexes indicate …

Most of the reported DNA structural studies are based on oligonucleotide structures, which
have artifacts due to unstable terminal base pairs (bps). We have carried out molecular …

Comprehensive analyses of structural features of non-canonical base pairs within a nucleic
acid double helix are limited by the availability of a small number of three dimensional …

The DNA duplex d-(CATGGGCCCATG) 2 has been studied in solution by FTIR, NMR and
CD. The experimental approaches have been complemented by series of large-scale …

The mechanism of protein-DNA recognition, particularly the induced fit mechanism, is poorly
understood due to ineffective analysis of the protein-DNA complex crystal structures. It is …

Abstract Effect of flanking base pairs on CA and AA dinluceotide step-geometry has been
studied using molecular dynamics method. Sixteen dodecameric sequences are constructed …

Synthetic molecules that target the major groove in a sequence-selective way are a major
goal in molecular medicine. Recently a major step has been taken toward achieving this …

We have developed a procedure for the enzymatic synthesis of large quantities of
isotopically labeled oligodeoxyribonucleotides. This procedure is highly efficient, routinely …