The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

KATP channels are integral to the functions of many cells and tissues. The use of
electrophysiological methods has allowed for a detailed characterization of KATP channels …

Inflammasomes activate caspase-1 for processing and secretion of the cytokines interleukin-
1β (IL-1β) and IL-18. Cryopyrin/NALP3/NLRP3 is an essential component of inflammasomes …

ATP-sensitive potassium (KATP) channels are present in the surface and internal
membranes of cardiac, skeletal, and smooth muscle cells and provide a unique feedback …

ATP sensitive potassium channels (KATP) are so named because they open as cellular ATP
levels fall. This leads to membrane hyperpolarization and thus links cellular metabolism to …

BACKGROUND: J-wave syndromes have emerged conceptually to encompass the
pleiotropic expression of J-point abnormalities including Brugada syndrome (BrS) and early …

ATP-sensitive potassium (KATP) channels were first discovered in the heart 30 years ago.
Reconstitution of KATP channel activity by coexpression of members of the pore-forming …

ATP-binding cassette (ABC) proteins are highly conserved and widely expressed throughout
nature and found in all organisms, both prokaryotic and eukaryotic. They mediate myriad …

Since their discovery in cardiac myocytes more than 30 years ago, it has been recognized
that adenosine triphosphate-sensitive potassium (KATP) channels provide a very large …

Mutations in genes encoding KATP channel subunits have been reported for pancreatic
disorders and Cantú syndrome. Here, we report a syndrome in six patients from two families …