Gastric cancer pathology and underlying molecular mechanisms

HI Grabsch, P Tan - Digestive surgery, 2013 - karger.com
The development of gastric adenocarcinoma is a complex multistep process involving
multiple genetic alterations. Based on pathology, four different macroscopic types and at …

A pan-cancer proteomic perspective on The Cancer Genome Atlas

R Akbani, PKS Ng, HMJ Werner… - Nature …, 2014 - nature.com
Protein levels and function are poorly predicted by genomic and transcriptomic analysis of
patient tumours. Therefore, direct study of the functional proteome has the potential to …

[HTML][HTML] Challenges of deciphering gastric cancer heterogeneity

P Hudler - World Journal of Gastroenterology: WJG, 2015 - ncbi.nlm.nih.gov
Gastric cancer is in decline in most developed countries; however, it still accounts for a
notable fraction of global mortality and morbidity related to cancer. High-throughput methods …

Gene expression signature–based prognostic risk score in gastric cancer

JY Cho, JY Lim, JH Cheong, YY Park, SL Yoon… - Clinical cancer …, 2011 - AACR
Purpose: Despite continual efforts to develop a prognostic model of gastric cancer by using
clinical and pathologic parameters, a clinical test that can discriminate patients with good …

Identification of genes with a correlation between copy number and expression in gastric cancer

L Cheng, P Wang, S Yang, Y Yang, Q Zhang… - BMC medical …, 2012 - Springer
Background To elucidate gene expression associated with copy number changes, we
performed a genome-wide copy number and expression microarray analysis of 25 pairs of …

Genome-wide gene copy number and expression analysis of primary gastric tumors and gastric cancer cell lines

S Junnila, A Kokkola, ML Karjalainen-Lindsberg… - BMC cancer, 2010 - Springer
Background Gastric cancer is one of the most common malignancies worldwide and the
second most common cause of cancer related death. Gene copy number alterations play an …

Gene expression analysis identifies over‐expression of CXCL1, SPARC, SPP1, and SULF1 in gastric cancer

S Junnila, A Kokkola, T Mizuguchi… - Genes …, 2010 - Wiley Online Library
To elucidate gene expression signatures associated with gastric carcinogenesis, we
performed a genome‐wide expression analysis of 46 Finnish and 20 Japanese gastric …

WGCNA identification of TLR7 as a novel diagnostic biomarker, progression and prognostic indicator, and immunotherapeutic target for stomach adenocarcinoma

Q Yuan, Q Zhou, J Ren, G Wang, C Yin… - Cancer …, 2021 - Wiley Online Library
Stomach adenocarcinoma (STAD) is a malignant tumor with high histological heterogeneity.
However, the potential mechanism of STAD tumorigenesis remains to be elucidated. The …

Integrated genomic and functional analyses reveal glyoxalase I as a novel metabolic oncogene in human gastric cancer

F Hosoda, Y Arai, N Okada, H Shimizu, M Miyamoto… - Oncogene, 2015 - nature.com
Chromosomal abnormalities are good guideposts when hunting for cancer-related genes.
We analyzed copy number alterations of 163 primary gastric cancers using array-based …

Krüppel‐like factor 12 plays a significant role in poorly differentiated gastric cancer progression

Y Nakamura, T Migita, F Hosoda… - … journal of cancer, 2009 - Wiley Online Library
Gastric cancer is the second common malignant neoplasia in Japan, and its poorly
differentiated form is a deadly disease. To identify novel candidate oncogenes contributing …